EMD 23,448: Effects of a putative dopamine autoreceptor agonist in chorea

R. P. Newman, Carol A. Tamminga, Th N. Chase, P. A. LeWitt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A novel dopamine agonist, which stimulates presynaptic dopamine receptors in the experimental animal, was administered acutely to four patients with chorea. Abnormal involuntary movements worsened, plasma prolactin levels fell, and plasma growth hormone concentrations increased in all patients tested. These effects resemble those associated with a post-synaptic rather than presynaptic dopamine agonist, and thus raise some question about the ability of conventional dopaminomimetic screens to predict clinical activity.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalJournal of Neural Transmission
Issue number1-2
StatePublished - Mar 1 1985

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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