TY - JOUR
T1 - Elevated systolic blood pressure in preterm very-low-birth-weight infants ≤3 years of life
AU - Duncan, Andrea F.
AU - Heyne, Roy J.
AU - Morgan, Janet S.
AU - Ahmad, Naveed
AU - Rosenfeld, Charles R.
N1 - Funding Information:
Dr. Duncan received funding from a Marshall Klaus Research Award from the American Academy of Pediatrics, Section on Perinatal Pediatrics; additional support was provided by the George L. MacGregor Professorship awarded to Dr. Rosenfeld.
PY - 2011/7
Y1 - 2011/7
N2 - Preterm, very-low-birth-weight neonates (=1500 gm, VLBW) exhibit elevated systolic blood pressures (SBP) in adolescence and adulthood; however, the age of onset and causes are unknown. We assessed SBP in a cross-sectional study of VLBWinfants at 1, 2 and 3 years of age (n = 40 per cohort). SBP was manually measured using Doppler amplification (observed), and calm values were compared to reference ranges used for clinical purposes (expected). SBP was converted to age-, gender- and height-specific z-scores (SBPz). Perinatal variables and growth parameters measured between 6 and 36 months were assessed as predictors of an elevated SBP. Observed SBP and SBPz exceeded the expected value at each age (P<0.01); for example 1 year SBP was 94±10 (standard deviation) vs. 85±3 mmHg, respectively. Although the expected SBP rose from 85±3 to 90±3 mmHg with advancing age (P<0.05), VLBW SBP was unchanged (P>0.1), averaging 93 mmHg across ages. Height and weight z-scores were below expected (P<0.01), while weight-for-height z-scores exceeded zero at 6, 12 and 24 months (P<0.05). Male subscapular skinfold thickness:abdominal circumference ratio decreased with advancing age, paralleling the decreases in SBPz. The VLBW neonates demonstrated an elevated SBP as early as 1 year of age. Although predictive perinatal variables were not identified, gender-specific relationships between infant growth and SBP were observed.
AB - Preterm, very-low-birth-weight neonates (=1500 gm, VLBW) exhibit elevated systolic blood pressures (SBP) in adolescence and adulthood; however, the age of onset and causes are unknown. We assessed SBP in a cross-sectional study of VLBWinfants at 1, 2 and 3 years of age (n = 40 per cohort). SBP was manually measured using Doppler amplification (observed), and calm values were compared to reference ranges used for clinical purposes (expected). SBP was converted to age-, gender- and height-specific z-scores (SBPz). Perinatal variables and growth parameters measured between 6 and 36 months were assessed as predictors of an elevated SBP. Observed SBP and SBPz exceeded the expected value at each age (P<0.01); for example 1 year SBP was 94±10 (standard deviation) vs. 85±3 mmHg, respectively. Although the expected SBP rose from 85±3 to 90±3 mmHg with advancing age (P<0.05), VLBW SBP was unchanged (P>0.1), averaging 93 mmHg across ages. Height and weight z-scores were below expected (P<0.01), while weight-for-height z-scores exceeded zero at 6, 12 and 24 months (P<0.05). Male subscapular skinfold thickness:abdominal circumference ratio decreased with advancing age, paralleling the decreases in SBPz. The VLBW neonates demonstrated an elevated SBP as early as 1 year of age. Although predictive perinatal variables were not identified, gender-specific relationships between infant growth and SBP were observed.
KW - Adiposity
KW - Infant growth
KW - Perinatal-neonatal events
KW - Z-scores
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U2 - 10.1007/s00467-011-1833-x
DO - 10.1007/s00467-011-1833-x
M3 - Article
C2 - 21399900
AN - SCOPUS:80052441660
SN - 0931-041X
VL - 26
SP - 1115
EP - 1121
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 7
ER -