TY - JOUR
T1 - Elevated serum IL-8 is associated with the presence of hepatocellular carcinoma and independently predicts survival
AU - Welling, Theodore H.
AU - Fu, Sherry
AU - Wan, Shanshan
AU - Zou, Weiping
AU - Marrero, Jorge A.
N1 - Funding Information:
Grant Support: This study was supported by NIH grants CA151414 (THW), DK077707 (JAM), and the NIH through the University of Michigan’s Cancer Center Support Grant (5P30 CA46592).
PY - 2012/12
Y1 - 2012/12
N2 - Tumor immune responses have prognostic importance to hepatocellular carcinoma (HCC). Serum cytokines may differentiate HCC patients from cirrhotic patients or have prognostic significance. Serum IL-8 was elevated in 90 HCC patients compared to 180 cirrhotic controls, whereas IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-15, IL-17, IL-21, and VEGF were similar. IL-8 predicted HCC presence with an area under the receiver-operator curve (ROC) of 0.68. HCC patients with highest IL-8 had worse survival. Multivariate analysis showed that high IL-8 (HR 2.15; 95%CI:1.21-3.74) and stage (HR 1.92; 95%CI:1.22-3.97) independently predicted mortality; while viral etiology was protective (HR 0.69; 95%CI:0.41-0.98). Therefore, HCC IL-8 mediated events may be worthy of future investigation.
AB - Tumor immune responses have prognostic importance to hepatocellular carcinoma (HCC). Serum cytokines may differentiate HCC patients from cirrhotic patients or have prognostic significance. Serum IL-8 was elevated in 90 HCC patients compared to 180 cirrhotic controls, whereas IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-15, IL-17, IL-21, and VEGF were similar. IL-8 predicted HCC presence with an area under the receiver-operator curve (ROC) of 0.68. HCC patients with highest IL-8 had worse survival. Multivariate analysis showed that high IL-8 (HR 2.15; 95%CI:1.21-3.74) and stage (HR 1.92; 95%CI:1.22-3.97) independently predicted mortality; while viral etiology was protective (HR 0.69; 95%CI:0.41-0.98). Therefore, HCC IL-8 mediated events may be worthy of future investigation.
KW - Cancer biology
KW - Cirrhosis
KW - Hepatocellular carcinoma
KW - Inflammation
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U2 - 10.3109/07357907.2012.732161
DO - 10.3109/07357907.2012.732161
M3 - Article
C2 - 23072563
AN - SCOPUS:84870663677
SN - 0735-7907
VL - 30
SP - 689
EP - 697
JO - Cancer Investigation
JF - Cancer Investigation
IS - 10
ER -