Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke

Jieyun Yin; Chongke Zhong; Zhengbao Zhu; Xiaoqing Bu; Tan Xu; Libing Guo; Xuemei Wang; Jintao Zhang; Yong Cui; Dong Li; Jianhui Zhang; Zhong Ju; Chung Shiuan Chen; Jing Chen; Yonghong Zhang; Jiang He

doi:10.1016/j.cca.2018.01.011

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke

Jieyun Yin, Chongke Zhong, Zhengbao Zhu, Xiaoqing Bu, Tan Xu, Libing Guo, Xuemei Wang, Jintao Zhang, Yong Cui, Dong Li, Jianhui Zhang, Zhong Ju, Chung Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. Methods: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis. PSD status was evaluated by 24-item Hamilton Depression Rating Scale at 3 months after stroke. Results: Two hundred and forty-one (40.30%) participants were considered as PSD. HCY and hs-CRP levels were not significantly different between PSD and non-PSD patients. Interesting, in a maximally adjusted model, the odds ratio (95% confidence interval) of PSD was 1.90 (1.18–3.06) for coexistence of HCY ≥ 14.65 μmol/l and hs-CRP ≥ 1.90 mg/l compared with the other levels (HCY < 14.65 μmol/l and/or hs-CRP < 1.90 mg/l). Adding combination of HCY and hs-CRP to a model containing conventional risk factors could significantly improve risk reclassification for PSD. Conclusions: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors.

Original language	English (US)
Pages (from-to)	132-137
Number of pages	6
Journal	Clinica Chimica Acta
Volume	479
DOIs	https://doi.org/10.1016/j.cca.2018.01.011
State	Published - Apr 2018

Keywords

Acute ischemic stroke
High sensitivity C reactive protein
Homocysteine
Post-stroke depression

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cca.2018.01.011

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Yin, J., Zhong, C., Zhu, Z., Bu, X., Xu, T., Guo, L., Wang, X., Zhang, J., Cui, Y., Li, D., Zhang, J., Ju, Z., Chen, C. S., Chen, J., Zhang, Y., & He, J. (2018). Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke. Clinica Chimica Acta, 479, 132-137. https://doi.org/10.1016/j.cca.2018.01.011

Yin, J, Zhong, C, Zhu, Z, Bu, X, Xu, T, Guo, L, Wang, X, Zhang, J, Cui, Y, Li, D, Zhang, J, Ju, Z, Chen, CS, Chen, J, Zhang, Y & He, J 2018, 'Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke', Clinica Chimica Acta, vol. 479, pp. 132-137. https://doi.org/10.1016/j.cca.2018.01.011

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title = "Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke",

abstract = "Background: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. Methods: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis. PSD status was evaluated by 24-item Hamilton Depression Rating Scale at 3 months after stroke. Results: Two hundred and forty-one (40.30%) participants were considered as PSD. HCY and hs-CRP levels were not significantly different between PSD and non-PSD patients. Interesting, in a maximally adjusted model, the odds ratio (95% confidence interval) of PSD was 1.90 (1.18–3.06) for coexistence of HCY ≥ 14.65 μmol/l and hs-CRP ≥ 1.90 mg/l compared with the other levels (HCY < 14.65 μmol/l and/or hs-CRP < 1.90 mg/l). Adding combination of HCY and hs-CRP to a model containing conventional risk factors could significantly improve risk reclassification for PSD. Conclusions: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors.",

keywords = "Acute ischemic stroke, High sensitivity C reactive protein, Homocysteine, Post-stroke depression",

author = "Jieyun Yin and Chongke Zhong and Zhengbao Zhu and Xiaoqing Bu and Tan Xu and Libing Guo and Xuemei Wang and Jintao Zhang and Yong Cui and Dong Li and Jianhui Zhang and Zhong Ju and Chen, {Chung Shiuan} and Jing Chen and Yonghong Zhang and Jiang He",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = apr,

doi = "10.1016/j.cca.2018.01.011",

language = "English (US)",

volume = "479",

pages = "132--137",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke

AU - Yin, Jieyun

AU - Zhong, Chongke

AU - Zhu, Zhengbao

AU - Bu, Xiaoqing

AU - Xu, Tan

AU - Guo, Libing

AU - Wang, Xuemei

AU - Zhang, Jintao

AU - Cui, Yong

AU - Li, Dong

AU - Zhang, Jianhui

AU - Ju, Zhong

AU - Chen, Chung Shiuan

AU - Chen, Jing

AU - Zhang, Yonghong

AU - He, Jiang

PY - 2018/4

Y1 - 2018/4

N2 - Background: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. Methods: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis. PSD status was evaluated by 24-item Hamilton Depression Rating Scale at 3 months after stroke. Results: Two hundred and forty-one (40.30%) participants were considered as PSD. HCY and hs-CRP levels were not significantly different between PSD and non-PSD patients. Interesting, in a maximally adjusted model, the odds ratio (95% confidence interval) of PSD was 1.90 (1.18–3.06) for coexistence of HCY ≥ 14.65 μmol/l and hs-CRP ≥ 1.90 mg/l compared with the other levels (HCY < 14.65 μmol/l and/or hs-CRP < 1.90 mg/l). Adding combination of HCY and hs-CRP to a model containing conventional risk factors could significantly improve risk reclassification for PSD. Conclusions: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors.

AB - Background: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. Methods: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis. PSD status was evaluated by 24-item Hamilton Depression Rating Scale at 3 months after stroke. Results: Two hundred and forty-one (40.30%) participants were considered as PSD. HCY and hs-CRP levels were not significantly different between PSD and non-PSD patients. Interesting, in a maximally adjusted model, the odds ratio (95% confidence interval) of PSD was 1.90 (1.18–3.06) for coexistence of HCY ≥ 14.65 μmol/l and hs-CRP ≥ 1.90 mg/l compared with the other levels (HCY < 14.65 μmol/l and/or hs-CRP < 1.90 mg/l). Adding combination of HCY and hs-CRP to a model containing conventional risk factors could significantly improve risk reclassification for PSD. Conclusions: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors.

KW - Acute ischemic stroke

KW - High sensitivity C reactive protein

KW - Homocysteine

KW - Post-stroke depression

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U2 - 10.1016/j.cca.2018.01.011

DO - 10.1016/j.cca.2018.01.011

M3 - Article

C2 - 29325799

AN - SCOPUS:85041382785

SN - 0009-8981

VL - 479

SP - 132

EP - 137

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke

Abstract

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