Elevated cerebrospinal fluid β-2 microglobulin as a tumor marker in a patient with myeloma of the central nervous system

Enaam M. Alsobhi; Ibrahim A. Hashim; Mohammad A. Abdelaal; Ahmad M. Aljifri; Abdelrahman M. Alshamy

Elevated cerebrospinal fluid β-2 microglobulin as a tumor marker in a patient with myeloma of the central nervous system

Enaam M. Alsobhi, Ibrahim A. Hashim, Mohammad A. Abdelaal, Ahmad M. Aljifri, Abdelrahman M. Alshamy

Research output: Contribution to journal › Article › peer-review

Abstract

Myeloma involvement of the nervous system is rare. Extensive literature review revealed only a few cases reported from different parts of the world. The presence of CNS symptoms and detection of plasma cells in the CSF is the usual basis of diagnosis. In addition. immunoelectrophoresis and immunofixation for detection of monoclonal protein confirm the diagnosis in some cases, while some authors used flow cytometry and cytogenetic studies on CSF. Reports of multiple myeloma also include unfavorable cytogenetic abnormalities of chromosome 13. We report a case with relapsed CNS multiple myeloma with the detection of elevated β-2 microglobulin (β2M) as a tumor marker in the CSF.

Original language	English (US)
Pages (from-to)	128-130
Number of pages	3
Journal	Saudi Medical Journal
Volume	28
Issue number	1
State	Published - Jan 1 2007

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Elevated cerebrospinal fluid β-2 microglobulin as a tumor marker in a patient with myeloma of the central nervous system",

abstract = "Myeloma involvement of the nervous system is rare. Extensive literature review revealed only a few cases reported from different parts of the world. The presence of CNS symptoms and detection of plasma cells in the CSF is the usual basis of diagnosis. In addition. immunoelectrophoresis and immunofixation for detection of monoclonal protein confirm the diagnosis in some cases, while some authors used flow cytometry and cytogenetic studies on CSF. Reports of multiple myeloma also include unfavorable cytogenetic abnormalities of chromosome 13. We report a case with relapsed CNS multiple myeloma with the detection of elevated β-2 microglobulin (β2M) as a tumor marker in the CSF.",

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AU - Abdelaal, Mohammad A.

AU - Aljifri, Ahmad M.

AU - Alshamy, Abdelrahman M.

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AB - Myeloma involvement of the nervous system is rare. Extensive literature review revealed only a few cases reported from different parts of the world. The presence of CNS symptoms and detection of plasma cells in the CSF is the usual basis of diagnosis. In addition. immunoelectrophoresis and immunofixation for detection of monoclonal protein confirm the diagnosis in some cases, while some authors used flow cytometry and cytogenetic studies on CSF. Reports of multiple myeloma also include unfavorable cytogenetic abnormalities of chromosome 13. We report a case with relapsed CNS multiple myeloma with the detection of elevated β-2 microglobulin (β2M) as a tumor marker in the CSF.

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Elevated cerebrospinal fluid β-2 microglobulin as a tumor marker in a patient with myeloma of the central nervous system

Abstract

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