TY - JOUR
T1 - Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on analysis of 3,697 patients
AU - Rude, Robert E.
AU - Poole, W. Kenneth
AU - Muller, James E.
AU - Turi, Zoltan
AU - Rutherford, John
AU - Parker, Corette
AU - Roberts, Robert
AU - Raabe, Daniel S.
AU - Gold, Herman K.
AU - Stone, Peter H.
AU - Willerson, James T.
AU - Braunwald, Eugene
N1 - Funding Information:
The research on which this publication is based was performed by the Multicenter Investigation of the Limitation of Infarct Size (MILIS) Group pursuant to contract numbers NOl-HV-7-2940, 7-2941, 7-2942 and 7-2979 with the National Heart, Lung, and Blood institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland. Manuscript received November 19, 1982; revised manuscript received July 27, 1983, accepted July 29, 1983.
PY - 1983/11/1
Y1 - 1983/11/1
N2 - Over a 34.5-month period, all admissions to 5 university hospital coronary care units were screened for eligibility for the Multicenter Investigation of the Limitation of Infarct Size (MILIS), an ongoing study of the effects of hyaluronidase, propranolol and placebo on myocardial infarct (MI) size. Of 3,697 patients with ≥ 30 minutes of discomfort that was thought to reflect myocardial ischemia who were assessed for the presence or absence of certain electrocardiographic abnormalities at the time of hospital admission, the electrocardiogram was considered predictive of acute Ml if ≥ 1 of the following abnormalities was present: new or presumably new Q waves (>- 30 ms wide and 0.20 mV deep) in at least 2 of the 3 diaphragmatic leads (II, III, aVF), or in at least 2 of the 6 precordial leads (V1 to V6), or in I and aVL; new or presumably new ST-segment elevation or depression of >- 0.10 mV in 1 of the same lead combinations; or complete left bundle branch block. In the screened population, the diagnostic sensitivity of the electrocardiographic criteria was 81 %, whereas the overall infarct rate in the total population screened was 49 %. The diagnostic specificity of these entry criteria was 69 % and the predictive value 72%. Further application of readily ascertainable study exclusion criteria (age > 75 years; qualifying symptoms commencing > 18 hours before presentation; previous MILIS participation; geographic, physical or psychological impediments to follow-up; cardiogenic shock; recent MI; and other major cardiac or medical problems likely to affect prognosis) resulted in an overall Ml rate of 86% in patients determined to be eligible. This represents the overall value of our criteria in selecting, before serial electrocardiographic or serum enzyme data are available, a population with a high prevalence of acute MI.
AB - Over a 34.5-month period, all admissions to 5 university hospital coronary care units were screened for eligibility for the Multicenter Investigation of the Limitation of Infarct Size (MILIS), an ongoing study of the effects of hyaluronidase, propranolol and placebo on myocardial infarct (MI) size. Of 3,697 patients with ≥ 30 minutes of discomfort that was thought to reflect myocardial ischemia who were assessed for the presence or absence of certain electrocardiographic abnormalities at the time of hospital admission, the electrocardiogram was considered predictive of acute Ml if ≥ 1 of the following abnormalities was present: new or presumably new Q waves (>- 30 ms wide and 0.20 mV deep) in at least 2 of the 3 diaphragmatic leads (II, III, aVF), or in at least 2 of the 6 precordial leads (V1 to V6), or in I and aVL; new or presumably new ST-segment elevation or depression of >- 0.10 mV in 1 of the same lead combinations; or complete left bundle branch block. In the screened population, the diagnostic sensitivity of the electrocardiographic criteria was 81 %, whereas the overall infarct rate in the total population screened was 49 %. The diagnostic specificity of these entry criteria was 69 % and the predictive value 72%. Further application of readily ascertainable study exclusion criteria (age > 75 years; qualifying symptoms commencing > 18 hours before presentation; previous MILIS participation; geographic, physical or psychological impediments to follow-up; cardiogenic shock; recent MI; and other major cardiac or medical problems likely to affect prognosis) resulted in an overall Ml rate of 86% in patients determined to be eligible. This represents the overall value of our criteria in selecting, before serial electrocardiographic or serum enzyme data are available, a population with a high prevalence of acute MI.
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U2 - 10.1016/0002-9149(83)90508-8
DO - 10.1016/0002-9149(83)90508-8
M3 - Article
C2 - 6356862
AN - SCOPUS:0021019511
SN - 0002-9149
VL - 52
SP - 936
EP - 941
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 8
ER -