TY - JOUR
T1 - Elderly-onset essential tremor is associated with dementia
AU - Benito-Leóon, Juliáan
AU - Louis, Elan D.
AU - Bermejo-Pareja, Félix
PY - 2006/5
Y1 - 2006/5
N2 - OBJECTIVE: To determine whether essential tremor (ET) is associated with prevalent dementia. METHODS: The authors identified all persons with dementia and ET in a population-based study in central Spain (the Neurological Disorders in Central Spain [NEDICES] Study). Dementia was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria. RESULTS: Thirty-one (11.4%) of 273 ET cases had dementia vs 204 (6.0%) of 3,382 non-ET subjects (controls) (odds ratio [OR] = 2.00, 95% CI = 1.34 to 2.98, p = 0.001). In a model that adjusted for age, stroke, and educational level, OR = 1.35, 95% CI = 0.87 to 2.18, and p = 0.17. In an adjusted model, ET cases with tremor onset after age 65 were 70% more likely to be demented than were controls (OR = 1.70, 95% CI = 1.04 to 2.76, p = 0.03), whereas ET cases with tremor onset at age ≤65 and controls were equally likely to be demented (OR = 0.38, 95% CI = 0.09 to 1.73, p = 0.21). CONCLUSIONS: Older-onset essential tremor (ET) was associated with dementia. Prospective studies are required to elucidate the association between ET and dementia.
AB - OBJECTIVE: To determine whether essential tremor (ET) is associated with prevalent dementia. METHODS: The authors identified all persons with dementia and ET in a population-based study in central Spain (the Neurological Disorders in Central Spain [NEDICES] Study). Dementia was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria. RESULTS: Thirty-one (11.4%) of 273 ET cases had dementia vs 204 (6.0%) of 3,382 non-ET subjects (controls) (odds ratio [OR] = 2.00, 95% CI = 1.34 to 2.98, p = 0.001). In a model that adjusted for age, stroke, and educational level, OR = 1.35, 95% CI = 0.87 to 2.18, and p = 0.17. In an adjusted model, ET cases with tremor onset after age 65 were 70% more likely to be demented than were controls (OR = 1.70, 95% CI = 1.04 to 2.76, p = 0.03), whereas ET cases with tremor onset at age ≤65 and controls were equally likely to be demented (OR = 0.38, 95% CI = 0.09 to 1.73, p = 0.21). CONCLUSIONS: Older-onset essential tremor (ET) was associated with dementia. Prospective studies are required to elucidate the association between ET and dementia.
UR - http://www.scopus.com/inward/record.url?scp=33745377335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745377335&partnerID=8YFLogxK
U2 - 10.1212/01.wnl.0000216134.88617.de
DO - 10.1212/01.wnl.0000216134.88617.de
M3 - Article
C2 - 16717208
AN - SCOPUS:33745377335
SN - 0028-3878
VL - 66
SP - 1500
EP - 1505
JO - Neurology
JF - Neurology
IS - 10
ER -