TY - JOUR
T1 - Efficacy of gatifloxacin in experimental Escherichia coli meningitis
AU - Lutsar, Irja
AU - Friedland, Ian R.
AU - Jafri, Hasan S.
AU - Wubbel, Loretta
AU - Ng, Winston
AU - Ghaffar, Faryal
AU - McCracken, George H.
PY - 1999/7
Y1 - 1999/7
N2 - The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a β-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime but similar to meropenem therapy (bacterial killing rates at 5 h, 0.83 ± 0.26, 0.46 ± 0.3, and 0.73 ± 0.17 CFU/ml/h, respectively; P = 0.03 for gatifloxacin versus cefotaxime). At 10 h, seven of eight animals treated with gatifloxacin had <10 CFU/ml in their cerebrospinal fluid, compared with one of seven treated with cefotaxime therapy (P = 0.01). Gatifloxacin was at least as effective as currently available antibiotics in this model of E. coli meningitis.
AB - The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a β-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime but similar to meropenem therapy (bacterial killing rates at 5 h, 0.83 ± 0.26, 0.46 ± 0.3, and 0.73 ± 0.17 CFU/ml/h, respectively; P = 0.03 for gatifloxacin versus cefotaxime). At 10 h, seven of eight animals treated with gatifloxacin had <10 CFU/ml in their cerebrospinal fluid, compared with one of seven treated with cefotaxime therapy (P = 0.01). Gatifloxacin was at least as effective as currently available antibiotics in this model of E. coli meningitis.
UR - http://www.scopus.com/inward/record.url?scp=0032789384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032789384&partnerID=8YFLogxK
U2 - 10.1128/aac.43.7.1805
DO - 10.1128/aac.43.7.1805
M3 - Article
C2 - 10390250
AN - SCOPUS:0032789384
SN - 0066-4804
VL - 43
SP - 1805
EP - 1807
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
ER -