TY - JOUR
T1 - Effects of γ-Aminobutyric Acid on Insulin, Glucagon, and Somatostatin Release from Isolated Perfused Dog Pancreas
AU - Kawai, K.
AU - Unger, Roger H
PY - 1983/7
Y1 - 1983/7
N2 - The effects of γ-aminobutyric acid (GABA) on the secretion of insulin, glucagon, and somatostatin were studied i n the isolated dog pancreas. Insulin secretion was inhibited in a dose-related fashion for 10 min or more by as little as 1 αM GABA. A prompt but small and transitory rise in somatostatin secretion, lasting only 1 min, occurred at GABA concentrations of 10 and 100 αM, levels that exert inhibitory effects on nervous tissue. Bicuculline, a GABA antagonist, inhibited insulin secretion and did not antagonize GABA-mediated insulin inhibition. The results suggest that GABA in concentrations that are known to exist in islet tissue can influence the secretion of islet hormones. (Endocrinology 113: 111, 1983).
AB - The effects of γ-aminobutyric acid (GABA) on the secretion of insulin, glucagon, and somatostatin were studied i n the isolated dog pancreas. Insulin secretion was inhibited in a dose-related fashion for 10 min or more by as little as 1 αM GABA. A prompt but small and transitory rise in somatostatin secretion, lasting only 1 min, occurred at GABA concentrations of 10 and 100 αM, levels that exert inhibitory effects on nervous tissue. Bicuculline, a GABA antagonist, inhibited insulin secretion and did not antagonize GABA-mediated insulin inhibition. The results suggest that GABA in concentrations that are known to exist in islet tissue can influence the secretion of islet hormones. (Endocrinology 113: 111, 1983).
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U2 - 10.1210/endo-113-1-111
DO - 10.1210/endo-113-1-111
M3 - Article
C2 - 6134611
AN - SCOPUS:0020512354
SN - 0013-7227
VL - 113
SP - 111
EP - 113
JO - Endocrinology
JF - Endocrinology
IS - 1
ER -