Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporter

Michel Baum, Vangipuram Dwarakanath, Robert J. Alpern, Orson W. Moe

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The neonatal proximal tubule has a lower rate of bicarbonate absorption than that of adults. This is due, in part, to a lower rate of apical membrane Na+/H+ antiporter activity. The purpose of these studies was to examine if thyroid hormone could be a factor in the maturational increase in Na+/H+ antiporter activity. Hypothyroid (0.01% propylthiouracil in drinking water starting at day 14 gestation and throughout the postnatal period), euthyroid, and hyperthyroid (intraperitoneal triiodothyronine, 10 μg/100 g body wt, once daily on days 17 to 20 of postnatal life) rats were all studied at 21 days of life. Renal cortical brush border Na+/H+ antiporter activity was 453 ± 24, 527 ± 30 and 608 ± 25 pmol/mg protein in the hypothyroid, euthyroid and hyperthyroid groups, respectively (P < 0.001). Hyperthyroid neonates had ~twofold greater renal cortical NHE-3 mRNA abundance than euthyroid and hypothyroid neonates (P < 0.05). Brush border membrane NHE-3 protein abundance in hypothyroid and hyperthyroid neonates was one-third and twofold that of euthyroid 21-day-old rats, respectively (P < 0.001). These data are consistent with a potential role of thyroid hormone in the postnatal increase in Na+/H+ antiporter activity.

Original languageEnglish (US)
Pages (from-to)1254-1258
Number of pages5
JournalKidney international
Issue number5
StatePublished - 1998


  • Brush border membrane vesicles
  • NHE-3
  • Proximal tubule
  • Renal development

ASJC Scopus subject areas

  • Nephrology


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