Effects of neuropeptide Y on the isolated rabbit iris dilator muscle

M. Piccone, J. Littzi, T. Krupin, R. A. Stone, M. Davis, M. B. Wax

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10-11 M to 10-6 M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylphrine (10-9 M to 10-4 M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10-6 M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5x10-6 M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.

Original languageEnglish (US)
Pages (from-to)330-332
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Issue number2
StatePublished - 1988

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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