Effects of diabetes mellitus on human ankle articular cartilage

J. Bosma; K. A. Athanasiou; J. G. Fleischli; T. J. Laughlin; C. F. Zhu; C. M. Agrawal; L. A. Lavery

Effects of diabetes mellitus on human ankle articular cartilage

J. Bosma, K. A. Athanasiou, J. G. Fleischli, T. J. Laughlin, C. F. Zhu, C. M. Agrawal, L. A. Lavery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The intrinsic material properties of tibiotalar joint articular cartilage were examined in fifteen diabetic and fifteen non-diabetic fresh-frozen human cadaveric ankles. Non-diabetic cartilage had the largest aggregate modulus H_A (1.32±0.56 MPa) and was found in the tibial anterior medial. The largest H_a for the diabetic group which was also found in the tibial anterior medial was 0.89±0.29 MPa. The biomechanical disparities between the diabetic and non-diabetic specimens suggest that clinically-observed cartilage pathologies may be associated with diabetes mellitus. This may be due to the fact that articular cartilage in diabetic subjects may no longer be functionally capable to withstand the strenuous joint environment.

Original language	English (US)
Title of host publication	Southern Biomedical Engineering Conference - Proceedings
Place of Publication	Piscataway, NJ, United States
Publisher	IEEE
Pages	29
Number of pages	1
State	Published - 1998
Event	Proceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA Duration: Feb 6 1998 → Feb 8 1998

Other

Other	Proceedings of the 1998 17th Southern Biomedical Engineering Conference
City	San Antonio, TX, USA
Period	2/6/98 → 2/8/98

ASJC Scopus subject areas

General Engineering

Cite this

@inproceedings{fd8d96cc00a04508bf8765b423a53958,

title = "Effects of diabetes mellitus on human ankle articular cartilage",

abstract = "The intrinsic material properties of tibiotalar joint articular cartilage were examined in fifteen diabetic and fifteen non-diabetic fresh-frozen human cadaveric ankles. Non-diabetic cartilage had the largest aggregate modulus HA (1.32±0.56 MPa) and was found in the tibial anterior medial. The largest Ha for the diabetic group which was also found in the tibial anterior medial was 0.89±0.29 MPa. The biomechanical disparities between the diabetic and non-diabetic specimens suggest that clinically-observed cartilage pathologies may be associated with diabetes mellitus. This may be due to the fact that articular cartilage in diabetic subjects may no longer be functionally capable to withstand the strenuous joint environment.",

author = "J. Bosma and Athanasiou, {K. A.} and Fleischli, {J. G.} and Laughlin, {T. J.} and Zhu, {C. F.} and Agrawal, {C. M.} and Lavery, {L. A.}",

year = "1998",

language = "English (US)",

pages = "29",

booktitle = "Southern Biomedical Engineering Conference - Proceedings",

publisher = "IEEE",

note = "Proceedings of the 1998 17th Southern Biomedical Engineering Conference ; Conference date: 06-02-1998 Through 08-02-1998",

}

TY - GEN

T1 - Effects of diabetes mellitus on human ankle articular cartilage

AU - Bosma, J.

AU - Athanasiou, K. A.

AU - Fleischli, J. G.

AU - Laughlin, T. J.

AU - Zhu, C. F.

AU - Agrawal, C. M.

AU - Lavery, L. A.

PY - 1998

Y1 - 1998

N2 - The intrinsic material properties of tibiotalar joint articular cartilage were examined in fifteen diabetic and fifteen non-diabetic fresh-frozen human cadaveric ankles. Non-diabetic cartilage had the largest aggregate modulus HA (1.32±0.56 MPa) and was found in the tibial anterior medial. The largest Ha for the diabetic group which was also found in the tibial anterior medial was 0.89±0.29 MPa. The biomechanical disparities between the diabetic and non-diabetic specimens suggest that clinically-observed cartilage pathologies may be associated with diabetes mellitus. This may be due to the fact that articular cartilage in diabetic subjects may no longer be functionally capable to withstand the strenuous joint environment.

AB - The intrinsic material properties of tibiotalar joint articular cartilage were examined in fifteen diabetic and fifteen non-diabetic fresh-frozen human cadaveric ankles. Non-diabetic cartilage had the largest aggregate modulus HA (1.32±0.56 MPa) and was found in the tibial anterior medial. The largest Ha for the diabetic group which was also found in the tibial anterior medial was 0.89±0.29 MPa. The biomechanical disparities between the diabetic and non-diabetic specimens suggest that clinically-observed cartilage pathologies may be associated with diabetes mellitus. This may be due to the fact that articular cartilage in diabetic subjects may no longer be functionally capable to withstand the strenuous joint environment.

UR - http://www.scopus.com/inward/record.url?scp=0031704064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031704064&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0031704064

SP - 29

BT - Southern Biomedical Engineering Conference - Proceedings

PB - IEEE

CY - Piscataway, NJ, United States

T2 - Proceedings of the 1998 17th Southern Biomedical Engineering Conference

Y2 - 6 February 1998 through 8 February 1998

ER -

Effects of diabetes mellitus on human ankle articular cartilage

Abstract

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ASJC Scopus subject areas

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