Abstract
The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 α-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.
Original language | English (US) |
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Pages (from-to) | 551-553 |
Number of pages | 3 |
Journal | Steroids |
Volume | 58 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1993 |
Keywords
- DNA synthesis
- Danazol
- endometrium
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
- Pharmacology
- Clinical Biochemistry
- Organic Chemistry