Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing

Jeffrey Buyten, Galen Kaufman, Matthew Ryan

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


HYPOTHESIS: Exposure to ciprofloxacin/dexamethasone, but not ofloxacin, prolongs tympanic membrane (TM) healing. BACKGROUND: Exposure to hydrocortisone has been shown to delay TM wound healing. No published studies have compared the effects of ciprofloxacin/dexamethasone and ofloxacin on TM healing. METHODS: Noninfected TM perforations were created in 30 rats. The rats were split into three groups, and ciprofloxacin/dexamethasone, ofloxacin, or isotonic sodium chloride solution drops were instilled for 8 days. Tympanic membrane healing was analyzed at specified intervals using photographic documentation verified by a blinded observer. RESULTS: The isotonic sodium chloride solution control and ofloxacin-exposed TMs healed at similar rates. There was a statistically significant delay in TM healing in the ciprofloxacin-/dexamethasone-exposed TMs by postoperative Day 10. However, all TM perforations were healed by postoperative Day 20. CONCLUSION: Ciprofloxacin/dexamethasone delays healing of experimental TM perforations, but the brief exposure in this study did not cause persistent perforations.

Original languageEnglish (US)
Pages (from-to)887-890
Number of pages4
JournalOtology and Neurotology
Issue number7
StatePublished - Oct 2007


  • Ciprodex
  • Ciprofloxacin/dexamethasone
  • Corticosteroids
  • Floxin
  • Glucocorticoids
  • Ofloxacin
  • Perforation
  • Tympanic membrane
  • Wound healing

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology


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