Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog

W. R. Beavers

Research output: Contribution to journalArticlepeer-review


Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.

Original languageEnglish (US)
Pages (from-to)711-712
Number of pages2
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number4
StatePublished - Apr 1960

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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