TY - JOUR
T1 - Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
AU - Sakamoto, S.
AU - Furuichi, R.
AU - Matsuda, M.
AU - Kudo, H.
AU - Suzuki, S.
AU - Sugiura, Y.
AU - Kuwa, K.
AU - Tajima, M.
AU - Matsubara, M.
AU - Namiki, H.
PY - 1994
Y1 - 1994
N2 - Sho-saiko-to (SST) and Juzen-taiho-to (JTT), Japanese modified Chinese herbal prescriptions, suppressed the activities of thymidylate synthetase and thymidine kinase involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively, in mammary tumors of SHN mice with the reduction of serum prolactin level. These results indicate that SST and JTT may have the antitumor effects on mammary tumors.
AB - Sho-saiko-to (SST) and Juzen-taiho-to (JTT), Japanese modified Chinese herbal prescriptions, suppressed the activities of thymidylate synthetase and thymidine kinase involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively, in mammary tumors of SHN mice with the reduction of serum prolactin level. These results indicate that SST and JTT may have the antitumor effects on mammary tumors.
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U2 - 10.1142/s0192415x94000061
DO - 10.1142/s0192415x94000061
M3 - Article
C2 - 8030618
AN - SCOPUS:0028187913
SN - 0192-415X
VL - 22
SP - 43
EP - 50
JO - Comparative Medicine East and West
JF - Comparative Medicine East and West
IS - 1
ER -