Effect of water-soluble carbodiimide on gating in sodium channels

G. N. Mozhayeva, A. P. Naumov, E. D. Nosyreva

Research output: Contribution to journalArticlepeer-review


The treatment of nodal membrane with water-soluble carbodiimide results in a deceleration of the time-course of activation and inactivation of Na+ channels and in a decrease in the steepness of the voltage-dependence of the channel gating. The effective charge of activation decreases from about 5 to 3 electronic charges. Carbodiimide is effective only at low (4.3-4.9) pH, which means that it reacts most probably with carboxyl groups. The data are consistent with the proposal that carboxyl groups may serve as 'gating particles'.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalBBA - Biomembranes
Issue number2
StatePublished - Jul 25 1984


  • (R. riribunda)
  • Carbodiimide
  • Gating charge
  • Ion channel
  • Na channel
  • Nerve membrane
  • Voltage clamp

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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