Effect of parathyroidectomy on serum lα,25-dihydroxyvitamin d and intestinal calcium absorption in primary hyperparathyroidism

H. G. Bone; J. E. Zerwekh; M. R. Haussler; C. Y C Pak

doi:10.1210/jcem-48-5-877

Effect of parathyroidectomy on serum lα,25-dihydroxyvitamin d and intestinal calcium absorption in primary hyperparathyroidism

H. G. Bone, J. E. Zerwekh, M. R. Haussler, C. Y C Pak

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Abstract

Serum concentration of lα,25-dihydroxyvitamin D [1,25(OH)₂D] and intestinal absorption were measured before and after parathyroidectomy in 11 patients with primary hyperparathyroidism. Serum 1,25(OH)₂D was high preoperatively (P < 0.001) and normal postoperatively. Ca absorption was elevated preoperatively (P < 0.001) and decreased significantly after parathyroidectomy (P < 0.001). However, 5 of 11 patients had a persistent hyperabsorption of Ca postoperatively, despite normal serum 1,25(OH)₂D. The results suggest that factors other than 1,25(OH)₂D contribute to the maintenance of high intestinal Ca absorption in hyperparathyroid patients in the postoperative state.

Original language	English (US)
Pages (from-to)	877-879
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	48
Issue number	5
DOIs	https://doi.org/10.1210/jcem-48-5-877
State	Published - May 1979

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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title = "Effect of parathyroidectomy on serum lα,25-dihydroxyvitamin d and intestinal calcium absorption in primary hyperparathyroidism",

abstract = "Serum concentration of lα,25-dihydroxyvitamin D [1,25(OH)2D] and intestinal absorption were measured before and after parathyroidectomy in 11 patients with primary hyperparathyroidism. Serum 1,25(OH)2D was high preoperatively (P < 0.001) and normal postoperatively. Ca absorption was elevated preoperatively (P < 0.001) and decreased significantly after parathyroidectomy (P < 0.001). However, 5 of 11 patients had a persistent hyperabsorption of Ca postoperatively, despite normal serum 1,25(OH)2D. The results suggest that factors other than 1,25(OH)2D contribute to the maintenance of high intestinal Ca absorption in hyperparathyroid patients in the postoperative state.",

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T1 - Effect of parathyroidectomy on serum lα,25-dihydroxyvitamin d and intestinal calcium absorption in primary hyperparathyroidism

AU - Bone, H. G.

AU - Zerwekh, J. E.

AU - Haussler, M. R.

AU - Pak, C. Y C

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N2 - Serum concentration of lα,25-dihydroxyvitamin D [1,25(OH)2D] and intestinal absorption were measured before and after parathyroidectomy in 11 patients with primary hyperparathyroidism. Serum 1,25(OH)2D was high preoperatively (P < 0.001) and normal postoperatively. Ca absorption was elevated preoperatively (P < 0.001) and decreased significantly after parathyroidectomy (P < 0.001). However, 5 of 11 patients had a persistent hyperabsorption of Ca postoperatively, despite normal serum 1,25(OH)2D. The results suggest that factors other than 1,25(OH)2D contribute to the maintenance of high intestinal Ca absorption in hyperparathyroid patients in the postoperative state.

AB - Serum concentration of lα,25-dihydroxyvitamin D [1,25(OH)2D] and intestinal absorption were measured before and after parathyroidectomy in 11 patients with primary hyperparathyroidism. Serum 1,25(OH)2D was high preoperatively (P < 0.001) and normal postoperatively. Ca absorption was elevated preoperatively (P < 0.001) and decreased significantly after parathyroidectomy (P < 0.001). However, 5 of 11 patients had a persistent hyperabsorption of Ca postoperatively, despite normal serum 1,25(OH)2D. The results suggest that factors other than 1,25(OH)2D contribute to the maintenance of high intestinal Ca absorption in hyperparathyroid patients in the postoperative state.

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Effect of parathyroidectomy on serum lα,25-dihydroxyvitamin d and intestinal calcium absorption in primary hyperparathyroidism

Abstract

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