TY - JOUR
T1 - Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities
AU - Aikawa, Shizu
AU - Ishii, Makoto
AU - Yanagisawa, Masashi
AU - Sakakibara, Yuzuru
AU - Sakurai, Takeshi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas “System study on higher-order brain functions” and a grant for anorexia nervosa research from the Japanese Ministry of Health, Labour and Welfare, and the 21st Century COE Program from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.
PY - 2008/11/29
Y1 - 2008/11/29
N2 - Decrease in food intake is commonly seen in the mammalian response to stress. Corticotropin-releasing factor (CRF) is a factor that modulates feeding behavior under these stressful conditions. We previously reported that neuropeptide B (NPB) exerts strong synergistic anorectic effects in mice when co-administered with CRF. Tissue distributions of neuropeptide B/W receptor-1 (NPBWR1) and NPB suggest that this neuropeptide system also plays a role in regulating emotion and stress responses. In this study, we examined whether the effects of NPB are altered by endogenous CRFergic tone. During the light period, NPB alone did not show any effect on feeding behavior when administered intracerebroventricularly in mice; however, NPB increased food intake when co-administered with astressin, a potent non-selective CRF receptor antagonist. On the other hand, during the dark period, administration of NPB resulted in a strong inhibition of feeding behavior. The effects were almost completely abolished when astressin was co-administered. Finally, after surgical stress, a semi-chronic stressor, NPB exerted potent anorectic effects on mice. In striking contrast, co-administration of astressin and NPB increased food intake under surgical stress conditions. These data suggest that the effects of NPB are greatly influenced by the endogenous CRFergic tone.
AB - Decrease in food intake is commonly seen in the mammalian response to stress. Corticotropin-releasing factor (CRF) is a factor that modulates feeding behavior under these stressful conditions. We previously reported that neuropeptide B (NPB) exerts strong synergistic anorectic effects in mice when co-administered with CRF. Tissue distributions of neuropeptide B/W receptor-1 (NPBWR1) and NPB suggest that this neuropeptide system also plays a role in regulating emotion and stress responses. In this study, we examined whether the effects of NPB are altered by endogenous CRFergic tone. During the light period, NPB alone did not show any effect on feeding behavior when administered intracerebroventricularly in mice; however, NPB increased food intake when co-administered with astressin, a potent non-selective CRF receptor antagonist. On the other hand, during the dark period, administration of NPB resulted in a strong inhibition of feeding behavior. The effects were almost completely abolished when astressin was co-administered. Finally, after surgical stress, a semi-chronic stressor, NPB exerted potent anorectic effects on mice. In striking contrast, co-administration of astressin and NPB increased food intake under surgical stress conditions. These data suggest that the effects of NPB are greatly influenced by the endogenous CRFergic tone.
KW - Feeding behavior
KW - G protein-coupled receptor 7
KW - Neuropeptide B/W receptor-1
KW - Neuropeptide W
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U2 - 10.1016/j.regpep.2008.08.001
DO - 10.1016/j.regpep.2008.08.001
M3 - Article
C2 - 18760311
AN - SCOPUS:56249126315
SN - 0167-0115
VL - 151
SP - 147
EP - 152
JO - Regulatory Peptides
JF - Regulatory Peptides
IS - 1-3
ER -