TY - JOUR
T1 - Effect of high-dose α-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease
AU - Devaraj, Sridevi
AU - Tang, Rong
AU - Huet, Beverley A
AU - Harris, Andrea
AU - Seenivasan, Thanalakshmi
AU - de Lemos, James A
AU - Jialal, Ishwarlal
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Background: Oxidative stress and inflammation are crucial in atherogenesis. α-Tocopherol is both an antioxidant and an antiinflammatory agent. Objective: We evaluated the effect of RRR-α-tocopherol supplementation on carotid atherosclerosis in patients with stable coronary artery disease (CAD) on drug therapy. Design: Randomized, controlled, double-blind trial compared RRR-α-tocopherol (1200 IU/d for 2 y) with placebo in 90 patients with CAD. Intimal medial thickness (IMT) of both carotid arteries was measured by high-resolution B-mode ultrasonography at 0, 1, 1.5, and 2 y. At 6-mo intervals, plasma α-tocopherol concentrations, C-reactive protein (CRP), LDL oxidation, monocyte function (superoxide anion release, cytokine release, and adhesion to endothelium), and urinary F2-isoprostanes were measured. Results: α-Tocopherol concentrations were significantly higher in the α-tocopherol group but not in the placebo group. High-sensitivity CRP concentrations were significantly lowered with α-tocopherol supplementation than with placebo (32%; P < 0.001). α-Tocopherol supplementation significantly reduced urinary F2-isoprostanes (P < 0.001) and monocyte superoxide anion and tumor necrosis factor release compared with baseline and placebo (P < 0.001). No significant difference was observed in the mean change in total carotid IMT in the placebo and α-tocopherol groups. In addition, no significant difference in cardiovascular events was observed (P = 0.21). Conclusions: High-dose RRR-α-tocopherol supplementation in patients with CAD was safe and significantly reduced plasma biomarkers of oxidative stress and inflammation but had no significant effect on carotid IMT during 2 y.
AB - Background: Oxidative stress and inflammation are crucial in atherogenesis. α-Tocopherol is both an antioxidant and an antiinflammatory agent. Objective: We evaluated the effect of RRR-α-tocopherol supplementation on carotid atherosclerosis in patients with stable coronary artery disease (CAD) on drug therapy. Design: Randomized, controlled, double-blind trial compared RRR-α-tocopherol (1200 IU/d for 2 y) with placebo in 90 patients with CAD. Intimal medial thickness (IMT) of both carotid arteries was measured by high-resolution B-mode ultrasonography at 0, 1, 1.5, and 2 y. At 6-mo intervals, plasma α-tocopherol concentrations, C-reactive protein (CRP), LDL oxidation, monocyte function (superoxide anion release, cytokine release, and adhesion to endothelium), and urinary F2-isoprostanes were measured. Results: α-Tocopherol concentrations were significantly higher in the α-tocopherol group but not in the placebo group. High-sensitivity CRP concentrations were significantly lowered with α-tocopherol supplementation than with placebo (32%; P < 0.001). α-Tocopherol supplementation significantly reduced urinary F2-isoprostanes (P < 0.001) and monocyte superoxide anion and tumor necrosis factor release compared with baseline and placebo (P < 0.001). No significant difference was observed in the mean change in total carotid IMT in the placebo and α-tocopherol groups. In addition, no significant difference in cardiovascular events was observed (P = 0.21). Conclusions: High-dose RRR-α-tocopherol supplementation in patients with CAD was safe and significantly reduced plasma biomarkers of oxidative stress and inflammation but had no significant effect on carotid IMT during 2 y.
KW - Atherosclerosis
KW - Carotid
KW - Coronary artery disease
KW - Inflammation
KW - Intimal media thickness
KW - Oxidative stress
KW - Vitamin E
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U2 - 10.1093/ajcn/86.5.1392
DO - 10.1093/ajcn/86.5.1392
M3 - Article
C2 - 17991651
AN - SCOPUS:36249001810
SN - 0002-9165
VL - 86
SP - 1392
EP - 1398
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -