TY - JOUR
T1 - Effect of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes
AU - Rosenfeld, Charles R.
AU - Morriss, Frank H.
AU - Battaglia, Frederick C.
AU - Makowski, Edgar L.
AU - Meschia, Giacomo
PY - 1976/3/15
Y1 - 1976/3/15
N2 - The effect of estradiol-17β (1 μg per kilogram) on regional blood flow and cardiac output was studied by means of radionuclide-labeled microspheres in 6 nonpregnant and 13 pregnant ewes five to seven days after operation. Estradiol caused vasodilation in myometrium, endometrium, and placental cotyledons throughout pregnancy, but these responses were significantly less than the fifteenfold increase seen in the nonpregnant uterine tissues. Significant vasodilation also occurred in the ovaries, cervix, vagina, uterine tubes, mammary gland, skin, and adrenal glands of pregnant ewes. Cardiac output increased by 14 per cent. No significant change in uterine oxygen consumption was associated with the increase in blood flow to the pregnant uterus.
AB - The effect of estradiol-17β (1 μg per kilogram) on regional blood flow and cardiac output was studied by means of radionuclide-labeled microspheres in 6 nonpregnant and 13 pregnant ewes five to seven days after operation. Estradiol caused vasodilation in myometrium, endometrium, and placental cotyledons throughout pregnancy, but these responses were significantly less than the fifteenfold increase seen in the nonpregnant uterine tissues. Significant vasodilation also occurred in the ovaries, cervix, vagina, uterine tubes, mammary gland, skin, and adrenal glands of pregnant ewes. Cardiac output increased by 14 per cent. No significant change in uterine oxygen consumption was associated with the increase in blood flow to the pregnant uterus.
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U2 - 10.1016/0002-9378(76)90064-8
DO - 10.1016/0002-9378(76)90064-8
M3 - Article
C2 - 1258914
AN - SCOPUS:0017106266
SN - 0002-9378
VL - 124
SP - 618
EP - 629
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 6
ER -