Effect of diphosphonate on crystallization of calcium oxalate in vitro

C. Y C Pak; M. Ohata; K. Holt

doi:10.1038/ki.1975.23

Effect of diphosphonate on crystallization of calcium oxalate in vitro

C. Y C Pak, M. Ohata, K. Holt

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Abstract

Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53x10^-9M², and was independent of duration of incubation, solid to solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium etidronate (disodium ethane 1 hydroxy 1, 1 diphosphonate; EHDP) on crystalization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.

Original language	English (US)
Pages (from-to)	154-160
Number of pages	7
Journal	Kidney international
Volume	7
Issue number	3
DOIs	https://doi.org/10.1038/ki.1975.23
State	Published - 1975

ASJC Scopus subject areas

Nephrology

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10.1038/ki.1975.23

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title = "Effect of diphosphonate on crystallization of calcium oxalate in vitro",

abstract = "Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53x10-9M2, and was independent of duration of incubation, solid to solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium etidronate (disodium ethane 1 hydroxy 1, 1 diphosphonate; EHDP) on crystalization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.",

author = "Pak, {C. Y C} and M. Ohata and K. Holt",

note = "Funding Information: This study was supported in part by Public Health Service research grant AM 16061, and by a grant from the Proctor and Gamble Company. The EHDP used in this investigation was supplied by Dr. Walter Hedglin of the Proctor and Gamble Company.",

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T1 - Effect of diphosphonate on crystallization of calcium oxalate in vitro

AU - Pak, C. Y C

AU - Ohata, M.

AU - Holt, K.

N1 - Funding Information: This study was supported in part by Public Health Service research grant AM 16061, and by a grant from the Proctor and Gamble Company. The EHDP used in this investigation was supplied by Dr. Walter Hedglin of the Proctor and Gamble Company.

PY - 1975

Y1 - 1975

N2 - Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53x10-9M2, and was independent of duration of incubation, solid to solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium etidronate (disodium ethane 1 hydroxy 1, 1 diphosphonate; EHDP) on crystalization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.

AB - Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53x10-9M2, and was independent of duration of incubation, solid to solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium etidronate (disodium ethane 1 hydroxy 1, 1 diphosphonate; EHDP) on crystalization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.

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Effect of diphosphonate on crystallization of calcium oxalate in vitro

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