Effect of diphosphonate on crystallization of calcium oxalate in vitro

C. Y C Pak, M. Ohata, K. Holt

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53x10-9M2, and was independent of duration of incubation, solid to solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium etidronate (disodium ethane 1 hydroxy 1, 1 diphosphonate; EHDP) on crystalization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.

Original languageEnglish (US)
Pages (from-to)154-160
Number of pages7
JournalKidney international
Issue number3
StatePublished - 1975

ASJC Scopus subject areas

  • Nephrology


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