Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle

Bruno Escalante; David Erlij; J R Falck; John C. Mcgiff

doi:10.1126/science.1846705

Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle

Bruno Escalante, David Erlij, J R Falck, John C. Mcgiff

Biochemistry

Research output: Contribution to journal › Article › peer-review

208 Scopus citations

Abstract

In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of ⁸⁶Rb uptake-an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytocbrome P450 blockade of the effect of AA on ⁸⁶Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH.

Original language	English (US)
Pages (from-to)	799-802
Number of pages	4
Journal	Science
Volume	251
Issue number	4995
DOIs	https://doi.org/10.1126/science.1846705
State	Published - 1991

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1846705

Cite this

@article{e0be7e21db204e0d8a87535cfdebe27b,

title = "Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle",

abstract = "In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of 86Rb uptake-an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytocbrome P450 blockade of the effect of AA on 86Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH.",

author = "Bruno Escalante and David Erlij and Falck, {J R} and Mcgiff, {John C.}",

year = "1991",

doi = "10.1126/science.1846705",

language = "English (US)",

volume = "251",

pages = "799--802",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4995",

}

TY - JOUR

T1 - Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle

AU - Escalante, Bruno

AU - Erlij, David

AU - Falck, J R

AU - Mcgiff, John C.

PY - 1991

Y1 - 1991

N2 - In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of 86Rb uptake-an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytocbrome P450 blockade of the effect of AA on 86Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH.

AB - In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of 86Rb uptake-an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytocbrome P450 blockade of the effect of AA on 86Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH.

UR - http://www.scopus.com/inward/record.url?scp=0025801795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025801795&partnerID=8YFLogxK

U2 - 10.1126/science.1846705

DO - 10.1126/science.1846705

M3 - Article

C2 - 1846705

AN - SCOPUS:0025801795

SN - 0036-8075

VL - 251

SP - 799

EP - 802

JO - Science

JF - Science

IS - 4995

ER -

Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this