TY - JOUR
T1 - Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres
T2 - A novel castro retentive drug delivery system
AU - Soppimath, Kumaresh S.
AU - Aminabhavi, Tejraj M.
AU - Agnihotri, Sunil A.
AU - Mallikarjuna, Nadagouda N.
AU - Kulkarni, Padmakar V.
PY - 2006/4/5
Y1 - 2006/4/5
N2 - A gastro retentive drug-delivery system for nifedipine was developed by incorporating the drug in cellulose acetate hollow microspheres capable of floating on the gastric and intestinal fluid. The microspheres were prepared by solvent diffusion-evaporation technique in the presence of coexcipients like polyethylene glycol, dibutyl phthalate, and poly(e-caprolactone) using ethyl acetate as a dispersing solvent. Size of the microparticles depends upon the type and concentration of the excipient used. Microparticles exhibited floating properties on the simulated-gastric fluid for <12 h. Their percentage buoyancy followed the rank order of: blank (no coexcipients) > dibutyl phthalate > polyethylene glycol > poly(e-caprolactone) after 15 h of floating. Release of nifedepine was enhanced by the addition of coexcipients. The drug release followed non-Fickian transport in almost all formulations.
AB - A gastro retentive drug-delivery system for nifedipine was developed by incorporating the drug in cellulose acetate hollow microspheres capable of floating on the gastric and intestinal fluid. The microspheres were prepared by solvent diffusion-evaporation technique in the presence of coexcipients like polyethylene glycol, dibutyl phthalate, and poly(e-caprolactone) using ethyl acetate as a dispersing solvent. Size of the microparticles depends upon the type and concentration of the excipient used. Microparticles exhibited floating properties on the simulated-gastric fluid for <12 h. Their percentage buoyancy followed the rank order of: blank (no coexcipients) > dibutyl phthalate > polyethylene glycol > poly(e-caprolactone) after 15 h of floating. Release of nifedepine was enhanced by the addition of coexcipients. The drug release followed non-Fickian transport in almost all formulations.
KW - Drug-delivery systems
KW - Excipients
KW - Floating hollow microspheres
KW - Nifedipine
KW - Non-fickian transport
UR - http://www.scopus.com/inward/record.url?scp=33644928747&partnerID=8YFLogxK
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U2 - 10.1002/app.23192
DO - 10.1002/app.23192
M3 - Article
AN - SCOPUS:33644928747
SN - 0021-8995
VL - 100
SP - 486
EP - 494
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 1
ER -