Abstract
Background: The effect of alirocumab on potentially atherogenic lipoprotein subfractions was assessed in a post hoc analysis using the vertical auto profile (VAP) method. Methods: Patients from three Phase II studies with low-density lipoprotein cholesterol (LDL-C) ≥2.59 mmol/L (100 mg/dL) at baseline on stable statin therapy were randomised to receive subcutaneous alirocumab 50-150 mg every 2 weeks (Q2W) or 150-300 mg every 4 weeks (according to study) or placebo for 8-12 weeks. Samples from patients treated with alirocumab 150 mg Q2W (n = 74; dose common to all three trials) or placebo (n = 71) were analysed by VAP. Percent change in lipoprotein subfractions with alirocumab vs. placebo was analysed at Weeks 6, 8 or 12 using analysis of covariance. Results: Alirocumab significantly reduced LDL-C and the cholesterol content of subfractions LDL1, LDL2 and LDL3+4. Significant reductions were also observed in triglycerides, apolipoproteins CII and CIII and the cholesterol content of very low-density, intermediate-density, and remnant lipoproteins. Conclusion: Alirocumab achieved reductions across a spectrum of atherogenic lipoproteins in patients receiving background statin therapy.
Original language | English (US) |
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Article number | 28 |
Journal | Lipids in Health and Disease |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - Feb 13 2016 |
Keywords
- Alirocumab
- Hypercholesterolaemia
- Lipoprotein subfraction
- PCSK9
- VAP
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical