TY - JOUR
T1 - Early predictors of continuous positive airway pressure failure in preterm neonates
AU - Kakkilaya, Venkatakrishna
AU - Wagner, Sheron
AU - Mangona, Kate Louise M.
AU - Steven Brown, L.
AU - Jubran, Ihab
AU - He, Henry
AU - Savani, Rashmin C.
AU - Kapadia, Vishal S.
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Objective: To develop a prediction model to identify infants admitted on continuous positive airway pressure (CPAP) requiring intubation within seventy-two hours of life (HOL). Study design: Infants born ≤29 weeks’ gestational age between 2013 and April 2018 were randomly assigned to either a modeling cohort (MC) or a validation cohort (VC) in a 2:1 ratio. Variables available within two HOL were compared between the CPAP failure group (CFG) and the CPAP success group (CSG). Results: Of the 189 infants in the MC, 50% failed CPAP. Compared to CSG, infants in the CFG had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (RDS) and fraction of inspired oxygen (FiO2). A forward stepwise logistic regression modeling in both MC and VC showed that FiO2 >0.3 and radiographic severe RDS predicted CPAP failure. Conclusion: FiO2 >0.3 within two HOL and radiographic severe RDS predicts CPAP failure in preterm infants.
AB - Objective: To develop a prediction model to identify infants admitted on continuous positive airway pressure (CPAP) requiring intubation within seventy-two hours of life (HOL). Study design: Infants born ≤29 weeks’ gestational age between 2013 and April 2018 were randomly assigned to either a modeling cohort (MC) or a validation cohort (VC) in a 2:1 ratio. Variables available within two HOL were compared between the CPAP failure group (CFG) and the CPAP success group (CSG). Results: Of the 189 infants in the MC, 50% failed CPAP. Compared to CSG, infants in the CFG had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (RDS) and fraction of inspired oxygen (FiO2). A forward stepwise logistic regression modeling in both MC and VC showed that FiO2 >0.3 and radiographic severe RDS predicted CPAP failure. Conclusion: FiO2 >0.3 within two HOL and radiographic severe RDS predicts CPAP failure in preterm infants.
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U2 - 10.1038/s41372-019-0392-z
DO - 10.1038/s41372-019-0392-z
M3 - Article
C2 - 31089256
AN - SCOPUS:85065835734
SN - 0743-8346
VL - 39
SP - 1081
EP - 1088
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 8
ER -