Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy

Georg Oeltzschner, Nicolaas A.J. Puts, Kimberly L. Chan, Vincent O. Boer, Peter B. Barker, Richard A.E. Edden

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: To develop J-difference editing with parallel reconstruction in accelerated multivoxel (PRIAM) for simultaneous measurement in two separate brain regions of γ-aminobutyric acid (GABA) or glutathione. Methods: PRIAM separates signals from two simultaneously excited voxels using receiver-coil sensitivity profiles. PRIAM was implemented into Mescher-Garwood (MEGA) edited experiments at 3 Tesla (T), and validated by acquiring dual-voxel MEGA-PRIAM (and compared with conventional single-voxel MEGA-PRESS) spectra from a GABA/glutathione phantom, and 11 healthy participants. Results: MEGA-PRIAM effectively separated phantom spectra with ∼3–4% between-voxel contamination. GABA and glutathione measurements agreed well with those obtained using single-voxel MEGA-PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA- and glutathione-edited spectra were successfully reconstructed with a mean in vivo g-factor of 1.025 (typical voxel-center separation: 7–8 cm). MEGA-PRIAM experiments showed higher signal-to-noise ratio than sequential single-voxel experiments of the same total duration (mean improvement 1.38 ± 0.24). Conclusions: Simultaneous acquisition of J-difference-edited GABA or glutathione spectra from two voxels is feasible at 3 T. MEGA-PRIAM increases data acquisition rates compared with MEGA-PRESS by a factor of 2. Magn Reson Med 77:16–22, 2017.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalMagnetic resonance in medicine
Issue number1
StatePublished - Jan 1 2017
Externally publishedYes


  • GABA
  • GSH
  • brain
  • dual volume
  • edited MRS
  • multivoxel

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy'. Together they form a unique fingerprint.

Cite this