Dual-radiolabeled nanoparticle SPECT probes for bioimaging

Kvar C.L. Black; Walter J. Akers; Gail Sudlow; Baogang Xu; Richard Laforest; Samuel Achilefu

doi:10.1039/c4nr05269b

Dual-radiolabeled nanoparticle SPECT probes for bioimaging

Kvar C.L. Black, Walter J. Akers, Gail Sudlow, Baogang Xu, Richard Laforest, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A gold nanoparticle was radiolabeled with ¹²⁵I and ¹¹¹In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.

Original language	English (US)
Pages (from-to)	440-444
Number of pages	5
Journal	Nanoscale
Volume	7
Issue number	2
DOIs	https://doi.org/10.1039/c4nr05269b
State	Published - Jan 14 2015
Externally published	Yes

ASJC Scopus subject areas

General Materials Science

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title = "Dual-radiolabeled nanoparticle SPECT probes for bioimaging",

abstract = "A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.",

author = "Black, {Kvar C.L.} and Akers, {Walter J.} and Gail Sudlow and Baogang Xu and Richard Laforest and Samuel Achilefu",

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AU - Black, Kvar C.L.

AU - Akers, Walter J.

AU - Sudlow, Gail

AU - Xu, Baogang

AU - Laforest, Richard

AU - Achilefu, Samuel

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015/1/14

Y1 - 2015/1/14

N2 - A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.

AB - A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.

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Dual-radiolabeled nanoparticle SPECT probes for bioimaging

Abstract

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