Drug-induced acute liver failure

Research output: Contribution to journalReview articlepeer-review

161 Scopus citations


Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.

Original languageEnglish (US)
Pages (from-to)575-586
Number of pages12
JournalClinics in Liver Disease
Issue number4
StatePublished - Nov 2013


  • Coagulopathy
  • Encephalopathy
  • Hepatocyte injury
  • Liver transplantation

ASJC Scopus subject areas

  • Hepatology


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