Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Rupali Ugrankar; Jade Bowerman; Hanaa Hariri; Mintu Chandra; Kevin Chen; Marie France Bossanyi; Sanchari Datta; Sean Rogers; Kaitlyn M. Eckert; Gonçalo Vale; Alexia Victoria; Joseph Fresquez; Jeffrey G. McDonald; Steve Jean; Brett M. Collins; W. Mike Henne

doi:10.1016/j.devcel.2019.07.021

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Mintu Chandra, Kevin Chen, Marie France Bossanyi, Sanchari Datta, Sean Rogers, Kaitlyn M. Eckert, Gonçalo Vale, Alexia Victoria, Joseph Fresquez, Jeffrey G. McDonald, Steve Jean, Brett M. Collins, W. Mike Henne

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.

Original language	English (US)
Pages (from-to)	557-572.e5
Journal	Developmental cell
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2019.07.021
State	Published - Sep 9 2019

Keywords

Drosophila fat body
ER
ER-PM contact site
FA
FB
LD
PM
endoplasmic reticulum
fatty acid
lipid droplet
plasma membrane

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.07.021

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Ugrankar, R., Bowerman, J., Hariri, H., Chandra, M., Chen, K., Bossanyi, M. F., Datta, S., Rogers, S., Eckert, K. M., Vale, G., Victoria, A., Fresquez, J., McDonald, J. G., Jean, S., Collins, B. M., & Henne, W. M. (2019). Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes. Developmental cell, 50(5), 557-572.e5. https://doi.org/10.1016/j.devcel.2019.07.021

Ugrankar, R, Bowerman, J, Hariri, H, Chandra, M, Chen, K, Bossanyi, MF, Datta, S, Rogers, S, Eckert, KM, Vale, G, Victoria, A, Fresquez, J, McDonald, JG, Jean, S, Collins, BM & Henne, WM 2019, 'Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes', Developmental cell, vol. 50, no. 5, pp. 557-572.e5. https://doi.org/10.1016/j.devcel.2019.07.021

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title = "Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes",

abstract = "Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.",

keywords = "Drosophila fat body, ER, ER-PM contact site, FA, FB, LD, PM, endoplasmic reticulum, fatty acid, lipid droplet, plasma membrane",

author = "Rupali Ugrankar and Jade Bowerman and Hanaa Hariri and Mintu Chandra and Kevin Chen and Bossanyi, {Marie France} and Sanchari Datta and Sean Rogers and Eckert, {Kaitlyn M.} and Gon{\c c}alo Vale and Alexia Victoria and Joseph Fresquez and McDonald, {Jeffrey G.} and Steve Jean and Collins, {Brett M.} and Henne, {W. Mike}",

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year = "2019",

month = sep,

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doi = "10.1016/j.devcel.2019.07.021",

language = "English (US)",

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T1 - Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

AU - Ugrankar, Rupali

AU - Bowerman, Jade

AU - Hariri, Hanaa

AU - Chandra, Mintu

AU - Chen, Kevin

AU - Bossanyi, Marie France

AU - Datta, Sanchari

AU - Rogers, Sean

AU - Eckert, Kaitlyn M.

AU - Vale, Gonçalo

AU - Victoria, Alexia

AU - Fresquez, Joseph

AU - McDonald, Jeffrey G.

AU - Jean, Steve

AU - Collins, Brett M.

AU - Henne, W. Mike

PY - 2019/9/9

Y1 - 2019/9/9

N2 - Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.

AB - Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.

KW - Drosophila fat body

KW - ER

KW - ER-PM contact site

KW - FA

KW - FB

KW - LD

KW - PM

KW - endoplasmic reticulum

KW - fatty acid

KW - lipid droplet

KW - plasma membrane

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ER -

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Abstract

Keywords

ASJC Scopus subject areas

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