@article{3ba82509ad654b86900555e697dae8bb,
title = "Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes",
abstract = "Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.",
keywords = "Drosophila fat body, ER, ER-PM contact site, FA, FB, LD, PM, endoplasmic reticulum, fatty acid, lipid droplet, plasma membrane",
author = "Rupali Ugrankar and Jade Bowerman and Hanaa Hariri and Mintu Chandra and Kevin Chen and Bossanyi, {Marie France} and Sanchari Datta and Sean Rogers and Eckert, {Kaitlyn M.} and Gon{\c c}alo Vale and Alexia Victoria and Joseph Fresquez and McDonald, {Jeffrey G.} and Steve Jean and Collins, {Brett M.} and Henne, {W. Mike}",
note = "Funding Information: The authors would like to thank Drs. Sandra Schmid and Joel Goodman for help and comments in preparing this manuscript. We also greatly thank Dr. Jen Liou for the MAPPER construct. We would also like to thank Drs. Kate Luby-Phelps and Anza Dareshouri for assistance with the TEM. We also thank Helmut Kramer, Drew Stenesen, Andrew Moehlman, and other members of the Kramer and Jon M. Graff labs for helpful comments and suggestions. This work is supported by grants from the Welch Foundation ( I-1873 ), the Searle Foundation ( SSP-2016-1482 ), the NIH NIGMS ( GM119768 ), AFAR ( A15198 ), and the UT Southwestern Endowed Scholars Program. B.M.C. is supported by an Australian National Health and Medical Research Council (NHMRC) Senior research fellowship ( APP1136021 ). J.G.M. is supported in part by NIH 2 PO1 HL20948-33 . Funding Information: The authors would like to thank Drs. Sandra Schmid and Joel Goodman for help and comments in preparing this manuscript. We also greatly thank Dr. Jen Liou for the MAPPER construct. We would also like to thank Drs. Kate Luby-Phelps and Anza Dareshouri for assistance with the TEM. We also thank Helmut Kramer, Drew Stenesen, Andrew Moehlman, and other members of the Kramer and Jon M. Graff labs for helpful comments and suggestions. This work is supported by grants from the Welch Foundation (I-1873), the Searle Foundation (SSP-2016-1482), the NIH NIGMS (GM119768), AFAR (A15198), and the UT Southwestern Endowed Scholars Program. B.M.C. is supported by an Australian National Health and Medical Research Council (NHMRC) Senior research fellowship (APP1136021). J.G.M. is supported in part by NIH 2 PO1 HL20948-33. W.M.H. and R.U. developed the overall concepts and experiments. S.J. J.B. M.-F.B. H.H. A.V. and S.D. assisted with fly experiments. H.H. conducted the Snz-GFP immuno-precipitation and proteomics experiments. S.D. performed experiments in the mammalian U2OS cells. S.R. assisted in data quantification. M.C. and B.M.C. performed the Snz PX structure modeling and liposome binding assays. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = sep,
day = "9",
doi = "10.1016/j.devcel.2019.07.021",
language = "English (US)",
volume = "50",
pages = "557--572.e5",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",
}