MDA-468 human breast cancer cells overexpress the EGFR and exhibit a functional TGFα-EGFR autocrine pathway. Loss of EGFR expression following stable transfection with an antisense EGFR cDNA containing plasmid down-regulates type T cAMP-dependent protein kinase (PKAI) expression with acquisition of cell growth resistance to the PKAI inhibitor 8-Cl-cAMP. These results suggest that PKAI expression and function are controlled by a TGFα-EGFR autocrine pathway in human breast cancer cells overexpressing the EGFR.
|Original language||English (US)|
|Number of pages||6|
|Journal||Breast Cancer Research and Treatment|
|State||Published - 1998|
- Growth factors
ASJC Scopus subject areas
- Cancer Research