TY - JOUR
T1 - Double-blinded randomized controlled trial of optimizing nutrition in preterm very low birth weight infants
T2 - Bayley scores at 18–38 months of age
AU - Reis, Jordan D.
AU - Tolentino-Plata, Kristine
AU - Caraig, Maria
AU - Heyne, Roy
AU - Rosenfeld, Charles R.
AU - Brown, L. Steven
AU - Brion, Luc P.
N1 - Funding Information:
The RCT was supported by a National Grant from the Gerber Foundation (LPB), George L. MacGregor Professorship (CRR) and Children’s Medical Center Clinical Advisory Committee (CCRAC)—Senior Investigator Research Award—New Direction (LPB). The follow-up was supported by the latter two sources. The study sponsors had no role in design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review and approval of the manuscript, and decision to submit the manuscript for publication.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023/1
Y1 - 2023/1
N2 - Background: Human milk supplementation for preterm infants in the neonatal intensive care unit (NICU) can be based on optimized nutrition (feeding adjustments based on growth and measurements of serum nutrients) or individualized nutrition (measurements of macronutrients in mother’s own milk). Objective: To compare Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) at 18–38mo adjusted age in infants who had been randomly allocated to individualized+optimized nutrition (experimental group) vs optimized nutrition alone (control) in the NICU. Methods: Double-blinded randomized controlled trial in neonates <29wks gestational age (GA) and those <34wks GA and small for GA. Results: Bayley scores were assessed in 91/114 (80%) infants. The two study groups had similar frequencies of low cognitive, motor and language Bayley scores and similar age-adjusted Bayley scores in bivariate and multivariate analyses. Conclusions: The type of human milk supplementation provided had no significant effect on Bayley scores assessed at 18–38mo. Trial registration: This randomized controlled trial was registered at ClinicalTrials.gov NCT02372136.
AB - Background: Human milk supplementation for preterm infants in the neonatal intensive care unit (NICU) can be based on optimized nutrition (feeding adjustments based on growth and measurements of serum nutrients) or individualized nutrition (measurements of macronutrients in mother’s own milk). Objective: To compare Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) at 18–38mo adjusted age in infants who had been randomly allocated to individualized+optimized nutrition (experimental group) vs optimized nutrition alone (control) in the NICU. Methods: Double-blinded randomized controlled trial in neonates <29wks gestational age (GA) and those <34wks GA and small for GA. Results: Bayley scores were assessed in 91/114 (80%) infants. The two study groups had similar frequencies of low cognitive, motor and language Bayley scores and similar age-adjusted Bayley scores in bivariate and multivariate analyses. Conclusions: The type of human milk supplementation provided had no significant effect on Bayley scores assessed at 18–38mo. Trial registration: This randomized controlled trial was registered at ClinicalTrials.gov NCT02372136.
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U2 - 10.1038/s41372-022-01572-6
DO - 10.1038/s41372-022-01572-6
M3 - Article
C2 - 36473929
AN - SCOPUS:85143444349
SN - 0743-8346
VL - 43
SP - 81
EP - 85
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 1
ER -