TY - JOUR
T1 - Dose-related levetiracetam-induced reticulated drug eruption
AU - Beswick, Tracy C.
AU - Cohen, Jack B.
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Cutaneous drug eruptions are to antiepileptic drugs (AEDs) used for seizure prophylaxis can range from a maculopapular eruption to severe Stevens-Johnson syndrome or toxic epidermal necrolysis. The aromatic drugs: phenytoin, carbamazepine, oxcarbazepine, phenobarbital, primidone, zonisamide and lamotrigine are the most common offenders. In contrast, the second generation AEDs like valproate, topiramate, gabapentin, tiagabine and levetiracetam are rarely associated with a rash. Doses of AEDs are often started low and gradually increased to decrease the risk of allergic reactions. Herein, the authors report a 46-year-old woman with malignant brain tumor, who developed a levetiracetam induced dose-related reticular eruption only after the initial post-operative dose 500 mg twice a day was increased to 1000 mg twice a day, and upon re-challenge when the slower titrated levetiracetam dose reached 750 mg twice a day.
AB - Cutaneous drug eruptions are to antiepileptic drugs (AEDs) used for seizure prophylaxis can range from a maculopapular eruption to severe Stevens-Johnson syndrome or toxic epidermal necrolysis. The aromatic drugs: phenytoin, carbamazepine, oxcarbazepine, phenobarbital, primidone, zonisamide and lamotrigine are the most common offenders. In contrast, the second generation AEDs like valproate, topiramate, gabapentin, tiagabine and levetiracetam are rarely associated with a rash. Doses of AEDs are often started low and gradually increased to decrease the risk of allergic reactions. Herein, the authors report a 46-year-old woman with malignant brain tumor, who developed a levetiracetam induced dose-related reticular eruption only after the initial post-operative dose 500 mg twice a day was increased to 1000 mg twice a day, and upon re-challenge when the slower titrated levetiracetam dose reached 750 mg twice a day.
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M3 - Article
C2 - 20514803
AN - SCOPUS:77953628370
SN - 1545-9616
VL - 9
SP - 409
EP - 410
JO - Journal of Drugs in Dermatology
JF - Journal of Drugs in Dermatology
IS - 4
ER -