TY - JOUR
T1 - Dopaminergic rules of engagement for memory in Drosophila
AU - Kaun, Karla R.
AU - Rothenfluh, Adrian
N1 - Funding Information:
We would like to thank Y Aso for advice on neuronal expression patterns, KM Scaplen, E Petruccelli, NJ Mei, KM Nunez, N Ledru and G Shohat-Ophir for helpful comments on the manuscript. KR Kaun was supported by an award from the Richard and Susan Smith Family Foundation, Newton, MA and from a Brown Institute of Brain Science Center for Nervous System Function COBRE Project leader award (NIGMS 5P20GM103645-03 to J Sanes). A Rothenfluh was supported by the NIH (R01AA019526, R21AA022404, R21DA040439) and an Effie Marie Cain Scholarship in Biomedical Research from UT Southwestern.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Dopamine is associated with a variety of conserved responses across species including locomotion, sleep, food consumption, aggression, courtship, addiction and several forms of appetitive and aversive memory. Historically, dopamine has been most prominently associated with dynamics underlying reward, punishment, or salience. Recent emerging evidence from Drosophila supports a role in all of these functions, as well as additional roles in the interplay between external sensation and internal states and forgetting of the very memories dopamine helped encode. We discuss how cell-specific resolution and manipulation are elucidating the rules of dopamine's involvement in encoding valence and memory.
AB - Dopamine is associated with a variety of conserved responses across species including locomotion, sleep, food consumption, aggression, courtship, addiction and several forms of appetitive and aversive memory. Historically, dopamine has been most prominently associated with dynamics underlying reward, punishment, or salience. Recent emerging evidence from Drosophila supports a role in all of these functions, as well as additional roles in the interplay between external sensation and internal states and forgetting of the very memories dopamine helped encode. We discuss how cell-specific resolution and manipulation are elucidating the rules of dopamine's involvement in encoding valence and memory.
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U2 - 10.1016/j.conb.2016.12.011
DO - 10.1016/j.conb.2016.12.011
M3 - Review article
C2 - 28088703
AN - SCOPUS:85009062742
SN - 0959-4388
VL - 43
SP - 56
EP - 62
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -