Donor risk factors for graft failure in the cornea donor study

Joel Sugar, Monty Montoya, Mariya Dontchev, Jean Paul Tanner, Roy Beck, Robin Gal, Shawn Gallagher, Ronald Gaster, Ellen Heck, Edward J. Holland, Craig Kollman, Jackie Malling, Mark J. Mannis, Jason Woody

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


PURPOSE: The purpose of this study was to assess the relationship between donor factors and 5-year corneal graft survival in the Cornea Donor Study. METHODS: Donor corneas met criteria established by the Eye Bank Association of America, had an endothelial cell density of 2300 to 3300/mm, and were determined to be of good to excellent quality by the eye banks. Donor corneas were assigned using a random approach and surgeons were masked to information about the donor cornea including donor age. Surgery and postoperative care were performed according to the surgeons' usual routines and subjects were followed for 5 years. Donor and donor cornea factors were evaluated for their association with graft failure, which was defined as a regraft or a cloudy cornea that was sufficiently opaque to compromise vision for a minimum of 3 consecutive months. RESULTS: Graft failure was not significantly associated with the type of tissue retrieval (enucleation versus in situ), processing factors, timing of use of the cornea, or characteristics of the donor or the donor cornea. Adjusting for donor age did not affect the results. CONCLUSION: Donor and donor cornea characteristics do not impact graft survival rates for corneas comparable in quality to those used in this study.

Original languageEnglish (US)
Pages (from-to)981-985
Number of pages5
Issue number9
StatePublished - Oct 2009


  • Cornea donor
  • Cornea transplant
  • Graft failure

ASJC Scopus subject areas

  • Ophthalmology


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