TY - JOUR
T1 - Donor-Derived Long-Term Multilineage Hematopoiesis in a Liver-Transplant Recipient
AU - Collins, Robert H.
AU - Anastasi, John
AU - Terstappen, Leon W M M
AU - Nikaein, Afzal
AU - Feng, Jiajia
AU - Fay, Joseph W.
AU - Klintmalm, Goran
AU - Stone, Marvin J.
PY - 1993/3/18
Y1 - 1993/3/18
N2 - Graft-versus-host disease (GVHD) has been well documented in several recipients of liver transplants1–8. In this syndrome alloreactive cells from the donor attack the recipient's skin, gastrointestinal tissue, and hematopoietic tissue. Severe myelosuppression commonly results, but there has been a degree of recovery of hematopoiesis in some patients after immunosuppressive therapy. The recovery of hematopoiesis resulted from the recovery of the recipient's bone marrow in some cases,1,3 but it also could be due to the proliferation of hematopoietic precursor cells in the donor's liver, since the liver is a site of hematopoiesis in fetuses and, under certain circumstances,…
AB - Graft-versus-host disease (GVHD) has been well documented in several recipients of liver transplants1–8. In this syndrome alloreactive cells from the donor attack the recipient's skin, gastrointestinal tissue, and hematopoietic tissue. Severe myelosuppression commonly results, but there has been a degree of recovery of hematopoiesis in some patients after immunosuppressive therapy. The recovery of hematopoiesis resulted from the recovery of the recipient's bone marrow in some cases,1,3 but it also could be due to the proliferation of hematopoietic precursor cells in the donor's liver, since the liver is a site of hematopoiesis in fetuses and, under certain circumstances,…
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U2 - 10.1056/NEJM199303183281104
DO - 10.1056/NEJM199303183281104
M3 - Article
C2 - 8094887
AN - SCOPUS:0027503139
SN - 0028-4793
VL - 328
SP - 762
EP - 765
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 11
ER -