DNA Repair

E. C. Friedberg

doi:10.1016/B978-0-12-374984-0.00430-7

DNA Repair

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This article discusses the multitude of mechanisms by which living cells repair spontaneous environmentally induced DNA damage. These include the removal of base damage from the genome by enzyme-catalyzed excision, the direct reversal of base damage by single-step enzyme-catalyzed reactions, and the repair of strand breaks in DNA. The relationships between defective DNA repair and human disease and the generation of mouse models of such diseases are also discussed.

Original language	English (US)
Title of host publication	Brenner's Encyclopedia of Genetics
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	380-385
Number of pages	6
ISBN (Electronic)	9780080961569
ISBN (Print)	9780123749840
DOIs	https://doi.org/10.1016/B978-0-12-374984-0.00430-7
State	Published - Feb 27 2013

Keywords

Base excision repair
Cellular responses to DNA damage
DNA repair
DNA strand breaks
Enzymatic photoreactivation
Hereditary nonpolyposis colon cancer
Mismatch repair
Mouse models of DNA repair
Nucleotide excision repair
O-alkylguanine
Reversal of damage
Xeroderma pigmentosum

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

Access to Document

10.1016/B978-0-12-374984-0.00430-7

Cite this

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title = "DNA Repair",

abstract = "This article discusses the multitude of mechanisms by which living cells repair spontaneous environmentally induced DNA damage. These include the removal of base damage from the genome by enzyme-catalyzed excision, the direct reversal of base damage by single-step enzyme-catalyzed reactions, and the repair of strand breaks in DNA. The relationships between defective DNA repair and human disease and the generation of mouse models of such diseases are also discussed.",

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AB - This article discusses the multitude of mechanisms by which living cells repair spontaneous environmentally induced DNA damage. These include the removal of base damage from the genome by enzyme-catalyzed excision, the direct reversal of base damage by single-step enzyme-catalyzed reactions, and the repair of strand breaks in DNA. The relationships between defective DNA repair and human disease and the generation of mouse models of such diseases are also discussed.

KW - Base excision repair

KW - Cellular responses to DNA damage

KW - DNA repair

KW - DNA strand breaks

KW - Enzymatic photoreactivation

KW - Hereditary nonpolyposis colon cancer

KW - Mismatch repair

KW - Mouse models of DNA repair

KW - Nucleotide excision repair

KW - O-alkylguanine

KW - Reversal of damage

KW - Xeroderma pigmentosum

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M3 - Chapter

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SN - 9780123749840

SP - 380

EP - 385

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -

DNA Repair

Abstract

Keywords

ASJC Scopus subject areas

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