Abstract
This article discusses the multitude of mechanisms by which living cells repair spontaneous environmentally induced DNA damage. These include the removal of base damage from the genome by enzyme-catalyzed excision, the direct reversal of base damage by single-step enzyme-catalyzed reactions, and the repair of strand breaks in DNA. The relationships between defective DNA repair and human disease and the generation of mouse models of such diseases are also discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 380-385 |
| Number of pages | 6 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| State | Published - Feb 27 2013 |
Keywords
- Base excision repair
- Cellular responses to DNA damage
- DNA repair
- DNA strand breaks
- Enzymatic photoreactivation
- Hereditary nonpolyposis colon cancer
- Mismatch repair
- Mouse models of DNA repair
- Nucleotide excision repair
- O-alkylguanine
- Reversal of damage
- Xeroderma pigmentosum
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)