DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

Anthony J. Davis; Benjamin P C Chen; David J. Chen

doi:10.1016/j.dnarep.2014.02.020

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

Anthony J. Davis, Benjamin P C Chen, David J. Chen

Research output: Contribution to journal › Article › peer-review

252 Scopus citations

Abstract

DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

Original language	English (US)
Pages (from-to)	21-29
Number of pages	9
Journal	DNA repair
Volume	17
DOIs	https://doi.org/10.1016/j.dnarep.2014.02.020
State	Published - May 2014

Keywords

DNA double strand breaks
DNA ligase IV
DNA-PKcs
Ku70/80
Non-homologous end-joining
XLF
XRCC4

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2014.02.020

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title = "DNA-PK: A dynamic enzyme in a versatile DSB repair pathway",

abstract = "DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.",

keywords = "DNA double strand breaks, DNA ligase IV, DNA-PKcs, Ku70/80, Non-homologous end-joining, XLF, XRCC4",

author = "Davis, {Anthony J.} and Chen, {Benjamin P C} and Chen, {David J.}",

note = "Funding Information: The authors are supported by National Institutes of Health grants ( CA162804 , CA92584 , and CA13499 to DJC and CA166677 to BPPC) and Cancer Prevention and Research Institute of Texas ( RP110465 to DJC).",

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journal = "DNA repair",

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T2 - A dynamic enzyme in a versatile DSB repair pathway

AU - Davis, Anthony J.

AU - Chen, Benjamin P C

AU - Chen, David J.

N1 - Funding Information: The authors are supported by National Institutes of Health grants ( CA162804 , CA92584 , and CA13499 to DJC and CA166677 to BPPC) and Cancer Prevention and Research Institute of Texas ( RP110465 to DJC).

PY - 2014/5

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N2 - DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

AB - DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

KW - DNA double strand breaks

KW - DNA ligase IV

KW - DNA-PKcs

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KW - Non-homologous end-joining

KW - XLF

KW - XRCC4

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JO - DNA repair

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DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

Abstract

Keywords

ASJC Scopus subject areas

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