DNA mismatch repair preferentially safeguards actively transcribed genes

Yaping Huang; Guo Min Li

doi:10.1016/j.dnarep.2018.08.010

DNA mismatch repair preferentially safeguards actively transcribed genes

Yaping Huang, Guo Min Li

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.

Original language	English (US)
Pages (from-to)	82-86
Number of pages	5
Journal	DNA repair
Volume	71
DOIs	https://doi.org/10.1016/j.dnarep.2018.08.010
State	Published - Nov 2018

Keywords

Actively-transcribed genes
H3K36me3
MSH6
Mutation frequency
Replication timing
Transcription-coupled repair

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2018.08.010

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title = "DNA mismatch repair preferentially safeguards actively transcribed genes",

abstract = "DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.",

keywords = "Actively-transcribed genes, H3K36me3, MSH6, Mutation frequency, Replication timing, Transcription-coupled repair",

author = "Yaping Huang and Li, {Guo Min}",

note = "Funding Information: We thank Jonathan Feinberg for helpful comments, and funds from the National Institutes of Health ( GM112702 and CA192003 ), the National Natural Science Foundation of China ( 31570814 , and 81630077 ). G.-M.L. holds the Reece A. Overcash, Jr. Chair for Research on Colon Cancer. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = nov,

doi = "10.1016/j.dnarep.2018.08.010",

language = "English (US)",

volume = "71",

pages = "82--86",

journal = "DNA repair",

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T1 - DNA mismatch repair preferentially safeguards actively transcribed genes

AU - Huang, Yaping

AU - Li, Guo Min

N1 - Funding Information: We thank Jonathan Feinberg for helpful comments, and funds from the National Institutes of Health ( GM112702 and CA192003 ), the National Natural Science Foundation of China ( 31570814 , and 81630077 ). G.-M.L. holds the Reece A. Overcash, Jr. Chair for Research on Colon Cancer. Publisher Copyright: © 2018 Elsevier B.V.

PY - 2018/11

Y1 - 2018/11

N2 - DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.

AB - DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.

KW - Actively-transcribed genes

KW - H3K36me3

KW - MSH6

KW - Mutation frequency

KW - Replication timing

KW - Transcription-coupled repair

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DO - 10.1016/j.dnarep.2018.08.010

M3 - Review article

C2 - 30174300

AN - SCOPUS:85052753875

SN - 1568-7864

VL - 71

SP - 82

EP - 86

JO - DNA repair

JF - DNA repair

ER -

DNA mismatch repair preferentially safeguards actively transcribed genes

Abstract

Keywords

ASJC Scopus subject areas

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