DNA mismatch repair preferentially safeguards actively transcribed genes

Yaping Huang, Guo Min Li

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.

Original languageEnglish (US)
Pages (from-to)82-86
Number of pages5
JournalDNA repair
StatePublished - Nov 2018


  • Actively-transcribed genes
  • H3K36me3
  • MSH6
  • Mutation frequency
  • Replication timing
  • Transcription-coupled repair

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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