DNA mismatch repair in the context of chromatin

Yaping Huang; Guo Min Li

doi:10.1186/s13578-020-0379-7

DNA mismatch repair in the context of chromatin

Yaping Huang, Guo Min Li

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.

Original language	English (US)
Article number	10
Journal	Cell and Bioscience
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13578-020-0379-7
State	Published - Feb 3 2020

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1186/s13578-020-0379-7

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abstract = "DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.",

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AB - DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.

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DNA mismatch repair in the context of chromatin

Abstract

ASJC Scopus subject areas

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