DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential

Yaping Huang; Guo Min Li

doi:10.1016/j.dnarep.2020.102918

DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential

Yaping Huang, Guo Min Li

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and precisely regulated in the context of chromatin; strikingly, tumors defective in MMR are highly responsive to immune checkpoint blockade therapy. As a tribute to Dr. Samuel Wilson for his many scientific contributions to the field of DNA repair and his leadership as Editor-in-Chief of the journal DNA Repair, we summarize recent developments in research on MMR at the chromatin level, its implications for tumorigenesis, and its therapeutic potential.

Original language	English (US)
Article number	102918
Journal	DNA repair
Volume	93
DOIs	https://doi.org/10.1016/j.dnarep.2020.102918
State	Published - Sep 2020

Keywords

Cancer therapy
Chromatin structure
Mimsatch repair
Replication fork

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2020.102918

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title = "DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential",

abstract = "DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and precisely regulated in the context of chromatin; strikingly, tumors defective in MMR are highly responsive to immune checkpoint blockade therapy. As a tribute to Dr. Samuel Wilson for his many scientific contributions to the field of DNA repair and his leadership as Editor-in-Chief of the journal DNA Repair, we summarize recent developments in research on MMR at the chromatin level, its implications for tumorigenesis, and its therapeutic potential.",

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AU - Li, Guo Min

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AB - DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and precisely regulated in the context of chromatin; strikingly, tumors defective in MMR are highly responsive to immune checkpoint blockade therapy. As a tribute to Dr. Samuel Wilson for his many scientific contributions to the field of DNA repair and his leadership as Editor-in-Chief of the journal DNA Repair, we summarize recent developments in research on MMR at the chromatin level, its implications for tumorigenesis, and its therapeutic potential.

KW - Cancer therapy

KW - Chromatin structure

KW - Mimsatch repair

KW - Replication fork

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DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential

Abstract

Keywords

ASJC Scopus subject areas

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