@article{b533a024add14b67be7ed1dfd2a83593,
title = "DNA double strand break repair via non-homologous end-joining",
abstract = "DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis-processing of DSBs can lead to genomic instability and carcinogenesis. One important pathway in eukaryotic cells responsible for the repair of DSBs is non-homologous end-joining (NHEJ). In this review we will discuss the interesting new insights into the mechanism of the NHEJ pathway and the proteins which mediate this repair process. Furthermore, the general role of NHEJ in promoting genomic stability will be discussed.",
keywords = "DNA double strand breaks, DNA-Ligase IV, DNA-PKcs, Ku70/80, Non-homologous end-joining, XLF, XRCC4",
author = "Davis, {Anthony J.} and Chen, {David J.}",
note = "Funding Information: Other Section Introduction DNA end recognition and assembly and stabilization of the NHEJ complex at the DNA double strand break Bridging of the DNA ends and promotion of end stability DNA end processing Ligation of the broken ends and dissolution of the NHEJ complex The role of DNA-PKcs kinase activity The role of NHEJ in promoting genome stability and cancer incidence Conclusions Acknowledgements References The research was supported by National Institutes of Health grants (CA162804, CA92584, and CA13499) and Cancer Prevention Research Institute of Texas (RP110465). The authors express their gratitude to Benjamin B.P. Chen for offering suggestions on the review. We apologize to all colleagues whose work we did not specifically mention in this review.",
year = "2013",
month = jun,
day = "1",
doi = "10.3978/j.issn.2218-676X.2013.04.02",
language = "English (US)",
volume = "2",
pages = "130--143",
journal = "Translational Cancer Research",
issn = "2218-676X",
publisher = "AME Publishing Company",
number = "3",
}