DNA-dependent protein kinase in telomere maintenance and protection

Jiangdong Sui; Shichuan Zhang; Benjamin P.C. Chen

doi:10.1186/s11658-020-0199-0

DNA-dependent protein kinase in telomere maintenance and protection

Jiangdong Sui, Shichuan Zhang, Benjamin P.C. Chen

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku and DNA-PKcs in telomere regulation.

Original language	English (US)
Article number	2
Journal	Cellular and Molecular Biology Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1186/s11658-020-0199-0
State	Published - Jan 17 2020

Keywords

DNA-PK
Shelterin
Telomerase
Telomere
hnRNP-A1

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1186/s11658-020-0199-0

Cite this

@article{33aa9bf7d34a46a199f561f6016d3222,

title = "DNA-dependent protein kinase in telomere maintenance and protection",

abstract = "This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku and DNA-PKcs in telomere regulation.",

keywords = "DNA-PK, Shelterin, Telomerase, Telomere, hnRNP-A1",

author = "Jiangdong Sui and Shichuan Zhang and Chen, {Benjamin P.C.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

month = jan,

day = "17",

doi = "10.1186/s11658-020-0199-0",

language = "English (US)",

volume = "25",

journal = "Cellular and Molecular Biology Letters",

issn = "1425-8153",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - DNA-dependent protein kinase in telomere maintenance and protection

AU - Sui, Jiangdong

AU - Zhang, Shichuan

AU - Chen, Benjamin P.C.

PY - 2020/1/17

Y1 - 2020/1/17

N2 - This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku and DNA-PKcs in telomere regulation.

AB - This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku and DNA-PKcs in telomere regulation.

KW - DNA-PK

KW - Shelterin

KW - Telomerase

KW - Telomere

KW - hnRNP-A1

UR - http://www.scopus.com/inward/record.url?scp=85078224408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078224408&partnerID=8YFLogxK

U2 - 10.1186/s11658-020-0199-0

DO - 10.1186/s11658-020-0199-0

M3 - Review article

C2 - 31988640

AN - SCOPUS:85078224408

SN - 1425-8153

VL - 25

JO - Cellular and Molecular Biology Letters

JF - Cellular and Molecular Biology Letters

IS - 1

M1 - 2

ER -

DNA-dependent protein kinase in telomere maintenance and protection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this