Diverse small non-coding RNAs in RNA interference pathways

Liande Li, Yi Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

52 Scopus citations


Large numbers of diverse small non-coding RNAs have been discovered and characterized in eukaryotic RNA interference pathways. These small RNAs have distinctive characteristics and are associated with Argonaute family proteins to regulate gene expression and genomes at various levels. These small RNAs include the Dicer-dependent group such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), and the Dicer-independent group such as Piwi-interacting RNAs (piRNAs). This review summarizes the various classes of eukaryotic small RNAs and the general knowledge of their characteristics, biogenesis, and functions, with emphasis on some of the recently identified small RNAs.

Original languageEnglish (US)
Title of host publicationTherapeutic Oligonucleotides
Subtitle of host publicationMethods and Protocols
EditorsJohn Goodchild
Number of pages14
StatePublished - Aug 4 2011

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • RNAi
  • miRNA
  • piRNA
  • qiRNA
  • siRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


Dive into the research topics of 'Diverse small non-coding RNAs in RNA interference pathways'. Together they form a unique fingerprint.

Cite this