Diverse mechanisms regulate stem cell self-renewal

Anna V. Molofsky, Ricardo Pardal, Sean J. Morrison

Research output: Contribution to journalReview articlepeer-review

261 Scopus citations


To what extent are the pathways that regulate self-renewal conserved between stem cells at different stages of development and in different tissues? Some pathways play a strikingly conserved role in regulating the self-renewal of diverse stem cells, whereas other pathways are specific to stem cells in certain tissues or at certain stages of development. Recent studies have highlighted differences between the self-renewal of embryonic, fetal and adult stem cells. By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Cell Biology


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