Diuretics: Correct use in hypertension

Norman M Kaplan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The use of diuretics for the treatment of hypertension had fallen significantly from 1990 until 1997, when their use again began to increase. Their recent return to popularity reflects 3 major factors: (1) the recognition of the effectiveness of much lower doses than used previously, thereby providing good antihypertensive action with fewer side effects; (2) the excellent reductions in morbidity and mortality achieved by low-dose diuretic-based therapy in multiple, randomized controlled trials in elderly hypertensives; and (3) the increasing recognition that some diuretic-induced shrinkage of effective blood volume is essential for adequate treatment of many, if not most, hypertensives.

Original languageEnglish (US)
Pages (from-to)559-574
Number of pages16
JournalSeminars in nephrology
Issue number6
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Diuretics: Correct use in hypertension'. Together they form a unique fingerprint.

Cite this