Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Polina Egorova; Elena Popugaeva; Ilya Bezprozvanny

doi:10.1016/j.semcdb.2015.03.010

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Polina Egorova, Elena Popugaeva, Ilya Bezprozvanny

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.

Original language	English (US)
Pages (from-to)	127-133
Number of pages	7
Journal	Seminars in Cell and Developmental Biology
Volume	40
DOIs	https://doi.org/10.1016/j.semcdb.2015.03.010
State	Published - Apr 1 2015

Keywords

Alzheimer's disease
Ataxia
Calcium
Polyglutamine expansion disorders
Store-operated calcium entry
Synapse

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2015.03.010

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title = "Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease",

abstract = "Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.",

keywords = "Alzheimer's disease, Ataxia, Calcium, Polyglutamine expansion disorders, Store-operated calcium entry, Synapse",

author = "Polina Egorova and Elena Popugaeva and Ilya Bezprozvanny",

note = "Funding Information: We are grateful to members of Ilya Bezprozvanny laboratory for advice and suggestions and to Leah Taylor and Polina Plotnikova for administrative assistance. IB is a holder of the Carl J. and Hortense M. Thomsen Chair in Alzheimer's Disease Research. PE is a holder of Presidential Stipend 2354.2013.4. This work was supported by the Dynasty Foundation grant DP-B-11/14 (EP) , by the contract with the Russian Ministry of Science 11.G34.31.0056 (IB), and by the Russian Scientific Fund grant 14-25-00024 (IB) (AD portion of the work). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

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doi = "10.1016/j.semcdb.2015.03.010",

language = "English (US)",

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T1 - Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

AU - Egorova, Polina

AU - Popugaeva, Elena

AU - Bezprozvanny, Ilya

N1 - Funding Information: We are grateful to members of Ilya Bezprozvanny laboratory for advice and suggestions and to Leah Taylor and Polina Plotnikova for administrative assistance. IB is a holder of the Carl J. and Hortense M. Thomsen Chair in Alzheimer's Disease Research. PE is a holder of Presidential Stipend 2354.2013.4. This work was supported by the Dynasty Foundation grant DP-B-11/14 (EP) , by the contract with the Russian Ministry of Science 11.G34.31.0056 (IB), and by the Russian Scientific Fund grant 14-25-00024 (IB) (AD portion of the work). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.

AB - Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.

KW - Alzheimer's disease

KW - Ataxia

KW - Calcium

KW - Polyglutamine expansion disorders

KW - Store-operated calcium entry

KW - Synapse

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DO - 10.1016/j.semcdb.2015.03.010

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SN - 1084-9521

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JO - Seminars in Cell and Developmental Biology

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Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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