Distribution of fibronectin on peripheral blood cells in freshly clotted blood

Frederick Grinnell; Marian K. Feld

doi:10.1016/0049-3848(81)90074-8

Distribution of fibronectin on peripheral blood cells in freshly clotted blood

Frederick Grinnell, Marian K. Feld

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Blood clots were prepared on plastic substrata and analyzed for fibronectin distribution using indirect immunofluorescence. Platelets generally were observed at focal points where numerous fibrin strands came together and the entire platelet-fibrin meshwork was covered with a uniform coating of fibronectin. In contrast to platelets, other peripheral blood cells observed had no fibronectin on their surfaces, including neutrophils, monocytes, eosinophils, lymphocytes, and red blood cells.

Original language	English (US)
Pages (from-to)	397-404
Number of pages	8
Journal	Thrombosis research
Volume	24
Issue number	5-6
DOIs	https://doi.org/10.1016/0049-3848(81)90074-8
State	Published - 1981

Keywords

Fibronectin
peripheral blood cells
plasma clots
platelet-fibrin interactions

ASJC Scopus subject areas

Hematology

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10.1016/0049-3848(81)90074-8

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@article{cb3620ed34c540bc9ca17c2c37ff998e,

title = "Distribution of fibronectin on peripheral blood cells in freshly clotted blood",

abstract = "Blood clots were prepared on plastic substrata and analyzed for fibronectin distribution using indirect immunofluorescence. Platelets generally were observed at focal points where numerous fibrin strands came together and the entire platelet-fibrin meshwork was covered with a uniform coating of fibronectin. In contrast to platelets, other peripheral blood cells observed had no fibronectin on their surfaces, including neutrophils, monocytes, eosinophils, lymphocytes, and red blood cells.",

keywords = "Fibronectin, peripheral blood cells, plasma clots, platelet-fibrin interactions",

author = "Frederick Grinnell and Feld, {Marian K.}",

note = "Funding Information: The technique for preparing blood clots on plastic was developed while one of us (F.G.) was on leave visiting J.P. Trinkaus in the Biology Department at Yale University. This research was supported by grants from the N.I.H. : CA14609 and HL24221.",

year = "1981",

doi = "10.1016/0049-3848(81)90074-8",

language = "English (US)",

volume = "24",

pages = "397--404",

journal = "Thrombosis research",

issn = "0049-3848",

publisher = "Elsevier Limited",

number = "5-6",

}

TY - JOUR

T1 - Distribution of fibronectin on peripheral blood cells in freshly clotted blood

AU - Grinnell, Frederick

AU - Feld, Marian K.

N1 - Funding Information: The technique for preparing blood clots on plastic was developed while one of us (F.G.) was on leave visiting J.P. Trinkaus in the Biology Department at Yale University. This research was supported by grants from the N.I.H. : CA14609 and HL24221.

PY - 1981

Y1 - 1981

N2 - Blood clots were prepared on plastic substrata and analyzed for fibronectin distribution using indirect immunofluorescence. Platelets generally were observed at focal points where numerous fibrin strands came together and the entire platelet-fibrin meshwork was covered with a uniform coating of fibronectin. In contrast to platelets, other peripheral blood cells observed had no fibronectin on their surfaces, including neutrophils, monocytes, eosinophils, lymphocytes, and red blood cells.

AB - Blood clots were prepared on plastic substrata and analyzed for fibronectin distribution using indirect immunofluorescence. Platelets generally were observed at focal points where numerous fibrin strands came together and the entire platelet-fibrin meshwork was covered with a uniform coating of fibronectin. In contrast to platelets, other peripheral blood cells observed had no fibronectin on their surfaces, including neutrophils, monocytes, eosinophils, lymphocytes, and red blood cells.

KW - Fibronectin

KW - peripheral blood cells

KW - plasma clots

KW - platelet-fibrin interactions

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DO - 10.1016/0049-3848(81)90074-8

M3 - Article

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AN - SCOPUS:0019767401

SN - 0049-3848

VL - 24

SP - 397

EP - 404

JO - Thrombosis research

JF - Thrombosis research

IS - 5-6

ER -

Distribution of fibronectin on peripheral blood cells in freshly clotted blood

Abstract

Keywords

ASJC Scopus subject areas

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