Disseminated herpesvirus infection during pregnancy

Edward J. Young, Edward Chafizadeh, Victor L. Oliveira, Robert M. Genta

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A case of disseminated herpes simplex virus infection during pregnancy is reported, and 26 similar cases are reviewed. The present case was unusual in that it occurred in the 12th week of gestation, whereas all but one of the other cases occurred in the second or third trimester. This rare complication is generally preceded by a flu-like prodrome with or without oral or genital lesions. The clinical presentation is (1) encephalitis without hepatic involvement, (2) hepatitis with or without central nervous system findings, or (3) disseminated akin lesions. When the liver is involved, rapidly progressive hepatic necrosis and severe coagulopathy are common and the mortality is high. Early diagnosis and early institution of antiviral chemotherapy with acyclovir greatly improve the outcome for both mother and infant.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalClinical Infectious Diseases
Issue number1
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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