Disposition of tetracycline by pregnant women with acute pyelonephritis

Peggy J. Whalley, Frances G. Martin, Reuben H. Adams, Burton Combes

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Studies to elucidate the mechanism responsible for tetracycline toxicity in pregnant women during an episode of acute pyelonephritis are reported. The rate at which tetracycline disappears from blood, the quantity excreted in urine, endogenous creatinine clearance, and liver function have been determined. From these and previous studies, it would appear that renal function impairment, which occurs during the course of acute pyelonephritis in pregnancy, is an important factor in the genesis of tetracycline toxicity.

Original languageEnglish (US)
Pages (from-to)821-826
Number of pages6
JournalObstetrics and gynecology
Issue number6
StatePublished - Dec 1970

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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